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1-isopropyldiazen-1-ium-1,2-diolate

releases nitroxyl in vivo; structure in first source

Also Known As:

IPA-NO; isopropylamine NONOate

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - 1-isopropyldiazen-1-ium-1,2-diolate: 7

Experts

1.	Kemp-Harper, Barbara K: 3 articles (09/2013 - 10/2011)
2.	Irvine, Jennifer C: 2 articles (09/2013 - 08/2013)
3.	Ambs, Stefan: 1 article (12/2014)
4.	Basudhar, Debashree: 1 article (12/2014)
5.	Cheng, Robert Y S: 1 article (12/2014)
6.	Glynn, Sharon: 1 article (12/2014)
7.	Heinecke, Julie L: 1 article (12/2014)
8.	Kesarwala, Aparna H: 1 article (12/2014)
9.	Miranda, Katrina M: 1 article (12/2014)
10.	Ridnour, Lisa A: 1 article (12/2014)

Related Diseases

1.	Hypertrophy 08/01/2013 - "Together these data strongly suggest that IPA-NO protection against cardiomyocyte hypertrophy is independent of both NO and CGRP but rather utilizes novel HNO activation of cGMP signaling. "
2.	Heart Failure 05/01/2010 - "Since HNO is being investigated as a treatment for congestive heart failure, our results raise some concerns about the use of IPA/NO in the vasculature and suggest that further studies be conducted on the safety of HNO donors in the cardiovascular system." 11/26/2012 - "All these data suggest that O(2)-sulfonylethyl protected derivatives of IPA/NO, which are efficient HNO donors, could have potential applications to treat cardiovascular disease(s) such as congestive heart failure."
3.	Hyperplasia 05/01/2010 - "The aims of this study are to determine the effect of IPA/NO on endothelial and vascular smooth muscle cells (VSMC) in vitro and to determine if IPA/NO inhibits neointimal hyperplasia in vivo. " 05/01/2010 - "In summary, while IPA/NO modestly inhibited neointimal hyperplasia by inhibiting VSMC proliferation and macrophage infiltration, it also inhibited endothelial cell proliferation and induced significant mortality in our animal model. " 05/01/2010 - "Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury." 05/01/2010 - "Isopropylamine NONOate (IPA/NO) is a nitroxyl (HNO) donor at physiologic pH. HNO is a positive inotrope and vasodilator, but little is known about its effect on neointimal hyperplasia. "
4.	Vascular System Injuries 05/01/2010 - "Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury."
5.	Carotid Artery Injuries 05/01/2010 - "In vivo, the carotid artery injury model was performed on male Sprague Dawley rats treated with (n = 12) or without (n = 6) periadventitial IPA/NO (10 mg). "

Related Drugs and Biologics

1.	1-isopropyldiazen-1-ium-1,2-diolate
2.	Vasodilator Agents (Vasodilators)
3.	1,1-diethyl-2-hydroxy-2-nitrosohydrazine
4.	nitroxyl
5.	Estrogen Receptors
6.	Prodrugs
7.	Nitroprusside (Sodium Nitroprusside)
8.	Aspirin (Acetylsalicylic Acid)