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PMS 777

an acetycholinesterase inhibitor

Also Known As:

PMS777

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - PMS 777: 5

Experts

1.	Heymans, Françoise: 4 articles (06/2009 - 12/2005)
2.	Li, Juan: 4 articles (06/2009 - 12/2005)
3.	Chen, Hongzhuan: 2 articles (06/2009 - 01/2008)
4.	Cui, Yongyao: 2 articles (06/2009 - 01/2008)
5.	Dong, Changzhi: 2 articles (06/2009 - 01/2008)
6.	Shao, Biyun: 2 articles (06/2009 - 01/2008)
7.	Miezan Ezoulin, Jean-Marc: 2 articles (01/2008 - 02/2007)
8.	Chen, Hong-Zhuan: 2 articles (02/2007 - 12/2005)
9.	Dong, Chang-Zhi: 2 articles (02/2007 - 12/2005)
10.	Massicot, France: 2 articles (02/2007 - 12/2005)

Related Diseases

1.	Cognitive Dysfunction 12/02/2005 - "Therefore, PMS777 could be of interest on patients with cognitive impairments and inflammatory damage, as in AD." 01/01/2008 - "We have previously reported that a novel tetrahydrofuran-derived bis-interacting ligand PMS777 had satisfying potencies for PAF receptor blockade and AChE inhibition, and markedly improved cholinergic dysfunction-induced cognitive impairment in mice. "
2.	Neuroblastoma 06/01/2009 - "PMS777 (1-100 microM) was found to inhibit Abeta-induced human neuroblastoma SH-SY5Y cell apoptosis in a concentration-dependent manner. " 01/01/2008 - "Continuing with our research, we further investigated the neuroprotective activities of PMS777 on PAF-triggered neuronal injury in human neuroblastoma SH-SY5Y cells. " 02/01/2007 - "PMS777 (1-100 microM) dose-dependently inhibited PAF-induced rabbit platelet aggregation by competing with [3H]PAF for its receptor on platelets, and protected a human neuroblastoma cell line SH-SY5Y against PAF-induced neurotoxicity. " 12/02/2005 - "Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells."
3.	Alzheimer Disease (Alzheimer's Disease) 02/01/2007 - "Taken together, these results demonstrate that PMS777 possesses dual activities for PAF receptor antagonism and AChE inhibition, suggesting that this compound may be a promising lead compound for further investigation related to the treatment for Alzheimer's disease." 06/01/2009 - "These results suggest that PMS777 potently protects against Abeta-induced neuronal apoptosis and neuroinflammation, and warrants further investigations in connection with its potential value in the treatment of Alzheimer's disease."
4.	Amnesia (Dissociative Amnesia) 09/01/2006 - "PMS777, both a PAF antagonist and a new potent acetylcholinesterase inhibitor was recently demonstrated to reverse scopolamine-induced amnesia in mice without toxicity. "
5.	Neuroinflammatory Diseases 06/01/2009 - "Continuing our efforts, we further investigated the protective effect of PMS777 on Abeta-induced neuronal apoptosis in vitro and neuroinflammation in vivo. " 06/01/2009 - "These results suggest that PMS777 potently protects against Abeta-induced neuronal apoptosis and neuroinflammation, and warrants further investigations in connection with its potential value in the treatment of Alzheimer's disease." 06/01/2009 - "Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation."

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Ligands
3.	tetrahydrofuran
4.	Cholinesterase Inhibitors (Anticholinesterases)
5.	Amyloid beta-Peptides
6.	Scopolamine (Hyoscine)
7.	Galantamine (Galanthamine)