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WMC-79

a potent agent against colon cancers; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - WMC-79: 1

Experts

1.	Cholody, W Marek: 1 article (10/2005)
2.	Kosakowska-Cholody, Teresa: 1 article (10/2005)
3.	Michejda, Christopher J: 1 article (10/2005)
4.	Monks, Anne: 1 article (10/2005)
5.	Woynarowska, Barbara A: 1 article (10/2005)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2005 - "WMC-79 is a synthetic agent with potent activity against colon and hematopoietic tumors. " 10/01/2005 - "However, whereas this pathway is important in wild-type p53 colon tumors, other pathways are also in operation because colon cancer cell lines in which the p53 gene is mutated are also affected by higher concentrations of WMC-79." 10/01/2005 - "We hypothesized that WMC-79 binding to DNA is recognized as an unrepairable damage in the tumor cells, which results in p53 activation. "
2.	Colonic Neoplasms (Colon Cancer) 10/01/2005 - "WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway." 10/01/2005 - "However, whereas this pathway is important in wild-type p53 colon tumors, other pathways are also in operation because colon cancer cell lines in which the p53 gene is mutated are also affected by higher concentrations of WMC-79."

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