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JNJ 10191584

histamine H4 receptor antagonist

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - JNJ 10191584: 4

Experts

1.	Galeotti, Nicoletta: 2 articles (02/2020 - 12/2015)
2.	Masini, Emanuela: 2 articles (02/2020 - 12/2015)
3.	Borgonetti, Vittoria: 1 article (02/2020)
4.	Sanna, Maria Domenica: 1 article (02/2020)
5.	Ghelardini, Carla: 1 article (12/2015)
6.	Lucarini, Laura: 1 article (12/2015)
7.	Sanna, Maria D: 1 article (12/2015)
8.	Stark, Holger: 1 article (12/2015)
9.	Berko, Aniko: 1 article (10/2005)
10.	Dunford, Paul J: 1 article (10/2005)

Related Diseases

1.	Necrosis 10/17/2005 - "Treatment with JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration. "
2.	Hypersensitivity (Allergy) 02/05/2020 - "The clonidine-induced anti-hypersensitivity effect was prevented by intra LC pretreatment with JNJ 10191584. "
3.	Hyperalgesia 12/01/2015 - "ST-1006 counteracted mechanical allodynia in neuropathic mice, an effect prevented by the H4R antagonist JNJ 10191584. "
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/17/2023 - "The objective of this work was to investigate the impact of JNJ 10191584 (JNJ), a highly effective and specific H4R antagonist, on the development of experimental autoimmune encephalomyelitis (EAE) and to gain insight into the underlying mechanism involved. "
5.	Colitis 10/17/2005 - "The effects of the recently described highly selective histamine H(4) receptor antagonists JNJ 10191584 and JNJ 7777120 have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid over 3 days in the rat. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Peroxidase (Myeloperoxidase)
3.	Histamine (Histamine Dihydrochloride)
4.	Clonidine (ST 155)
5.	Acids
6.	1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazine
7.	N4- (2,6- dichlorobenzyl)- 6- (4- methylpiperazin- 1- yl)pyrimidine- 2,4- diamine