polyphenon B

09/01/2007 - "The present study provides evidence that Polyphenon-B exerts multifunctional inhibitory effects on DMBA-induced mammary carcinogenesis and suggests that it can be developed as a potential chemopreventive agent."
10/01/2006 - "Although dietary administration of bLF and Polyphenon-B alone significantly reduced tumour incidence, combined administration of bLF and Polyphenon-B was more effective in inhibiting HBP carcinogenesis by restoring normal cytokeratin expression, inhibiting cell proliferation and inducing apoptosis. "
05/01/2007 - "The present study provides evidence that Polyphenon-B exerts multifunctional inhibitory effects on MNNG-induced gastric carcinogenesis and suggests that it can be developed as a potential chemopreventive agent."
01/01/2006 - "Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. "
10/01/2005 - "The greater efficacy of Polyphenon-B in inhibiting HBP carcinogenesis suggests that it may have a major impact in the chemoprevention of oral cancer."

01/01/2007 - "Dietary administration of Polyphenon B significantly suppressed DMBA-induced HBP carcinomas by 20% and reduced the frequency of bone marrow micronuclei by 57.3% and TBARS and LOOH by 38.8% and 25.8%, respectively, compared to group 1 animals with significant elevations in the GSH:GSSG ratio (16.0%) and activities of GPx (29.8%) and GST (53.8%). "
03/01/2008 - "Although dietary administration of bLF and Polyphenon-B alone significantly reduced the tumor incidence, combined administration of bLF and polyphenon-B was more effective in inhibiting DMBA-induced genotoxicity and development of HBP carcinomas by modulation of carcinogen-metabolizing enzymes and cellular redox status. "
01/01/2008 - "The present study was designed to evaluate the in vitro antioxidant potential of bovine lactoferrin (bLF) and black tea polyphenols [Polyphenon-B (P-B)] as well as in vivo inhibitory effects on the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinomas. "

10/01/2005 - "The greater efficacy of Polyphenon-B in inhibiting HBP carcinogenesis suggests that it may have a major impact in the chemoprevention of oral cancer."
01/01/2006 - "Our study provides evidence that polyphenon-B is more effective in inhibiting HBP carcinogenesis than polyphenon-E by enhancing the antioxidant status, suggesting that polyphenon-B may have a major impact in the chemoprevention of oral cancer."

11/01/2010 - "Administration of Polyphenon-B induced dose-dependent inhibition of growth of HepG2 cells and reduced tumor incidence in DAB administered animals. "
01/01/2007 - "Our results suggest that Polyphenon-B may exert its chemopreventive effects by modulating mitochondrial cellular redox status in the tumor as well as in the host liver."
03/01/2008 - "Although dietary administration of bLF and Polyphenon-B alone significantly reduced the tumor incidence, combined administration of bLF and polyphenon-B was more effective in inhibiting DMBA-induced genotoxicity and development of HBP carcinomas by modulation of carcinogen-metabolizing enzymes and cellular redox status. "
01/01/2008 - "Administration of Polyphenon-B and BTF-35 significantly decreased tumor incidence, oxidative DNA damage, phase I enzyme activities as well as expression of CYP1A1 and CYP1B1 isoforms, while enhancing phase II enzyme activities in the buccal pouch and liver. "
09/01/2007 - "Dietary administration of Polyphenon-B effectively suppressed the incidence of mammary tumors as evidenced by modulation of xenobiotic-metabolizing enzymes and oxidant-antioxidant status, inhibition of cell proliferation and angiogenesis, and induction of apoptosis. "

10/01/2008 - "The present study was designed to investigate the modulatory effects of black tea polyphenols (Polyphenon-B) on phase I and phase II xenobiotic-metabolizing enzymes and oxidative stress in a rat model of hepatocellular carcinoma (HCC). "
06/01/2009 - "The administration of Polyphenon-B significantly reduced the incidence of DAB-induced hepatomas as evidenced by modulation of the markers of invasion (matrix metalloproteinase, MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinase, TIMP-2, and reversion-inducing cysteine rich protein with Kazal motifs RECK) and angiogenesis (hypoxia inducible factor 1alpha, HIF1alpha, vascular endothelial growth factor, VEGF, and VEGF receptor, VEGFR1) as well as the expression of histone deacetylase HDAC-1. "