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A-317567

acid sensing ion channel blocker; structure in first source

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - A-317567: 5
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        A-317567: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - A-317567: 5

Experts

1.	Araki, Isao: 1 article (01/2020)
2.	Kobayashi, Hideki: 1 article (01/2020)
3.	Takeda, Masayuki: 1 article (01/2020)
4.	Yoshiyama, Mitsuharu: 1 article (01/2020)
5.	Luo, Zhu-Rong: 1 article (01/2015)
6.	Song, Jing-Chun: 1 article (01/2015)
7.	Wang, Xian-Yue: 1 article (01/2015)
8.	Zhang, Xiao-Lan: 1 article (01/2015)
9.	Zhang, Zhi-Gang: 1 article (01/2015)
10.	Dinger, B: 1 article (12/2011)

Related Diseases

1.	Pain (Aches) 03/01/2010 - "A-317567 was effective in reversing hyperalgesia in these animals, suggesting the potential of ASICs as therapeutic targets for muscle inflammatory pain." 09/01/2005 - "In summary, A-317567 is the first reported small molecule non-amiloride blocker of ASIC that is peripherally active and is more potent than amiloride in vitro and in vivo pain models. "
2.	Hyperalgesia 03/01/2010 - "A-317567 was effective in reversing hyperalgesia in these animals, suggesting the potential of ASICs as therapeutic targets for muscle inflammatory pain." 09/01/2005 - "When evaluated in the rat Complete Freud's Adjuvant (CFA)-induced inflammatory thermal hyperalgesia model, A-317567 was fully efficacious at a dose 10-fold lower than amiloride. " 03/01/2010 - "A-317567 reverses both the primary and the secondary hyperalgesia induced by carrageenan muscle inflammation. "
3.	Abnormal Reflex (Hyperreflexia) 01/01/2020 - "A-317567 (30 μmol/kg i.p.) alleviated hyperreflexia by increasing the acid-shortened ICI by 76% (P < 0.001). " 01/01/2020 - "Meanwhile, intravesical perfusion of A-317567 (100 μM) had no effect on bladder activity during pH 6.0 saline infusion cystometry, and drug perfusion at neither 100 μM nor 1 mM produced any effects on bladder hyperreflexia during pH 3.0 acetic acid infusion cystometry. "
4.	Postoperative Pain 09/01/2005 - "A-317567 was also potent and fully efficacious when tested in the skin incision model of post-operative pain. "
5.	Inflammation (Inflammations) 03/01/2010 - "A-317567 reverses both the primary and the secondary hyperalgesia induced by carrageenan muscle inflammation. "

Related Drugs and Biologics

1.	Acid Sensing Ion Channels
2.	Acetic Acid (Vinegar)
3.	Carrageenan
4.	Amiloride (Midamor)
5.	Acids
6.	1,3- dihydroxy- 4,4,5,5- tetramethyl- 2- (4- carboxyphenyl)tetrahydroimidazole (NOR 1)