HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

HTS 466284

a TGFbeta-RI inhibitor; structure in first source

Also Known As:

HTS-466284; HTS466284; Ly-364947; SM305

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - HTS 466284: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - HTS 466284: 6

Experts

1.	Min, Wen-Pu: 1 article (06/2021)
2.	Wei, Xiao-Feng: 1 article (06/2021)
3.	Asashima, Makoto: 1 article (02/2015)
4.	Ezura, Yoichi: 1 article (02/2015)
5.	Hayata, Tadayoshi: 1 article (02/2015)
6.	Nishinakamura, Ryuichi: 1 article (02/2015)
7.	Noda, Masaki: 1 article (02/2015)
8.	Yoichi, Ezura: 1 article (02/2015)
9.	Grisanti, Salvatore: 1 article (06/2014)
10.	Grisanti, Swaantje: 1 article (06/2014)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2013 - "Combined use of gemcitabine (Gem) and LY-364947 (LY), a TGF-β1 receptor inhibitor, has shown promise for the treatment of fibrotic pancreatic cancer, by reducing collagen production and improving tumor drug penetration. "
2.	Neoplasms (Cancer) 08/01/2013 - "Combined use of gemcitabine (Gem) and LY-364947 (LY), a TGF-β1 receptor inhibitor, has shown promise for the treatment of fibrotic pancreatic cancer, by reducing collagen production and improving tumor drug penetration. "
3.	Proliferative Vitreoretinopathy 06/01/2014 - "This study evaluates the use of the TGF-β receptor 1 inhibitor LY-364947 (LY) to prevent proliferative vitreoretinopathy (PVR). "
4.	Neoplasm Metastasis (Metastasis) 06/01/2021 - "In addition, the expressions of TGFβ1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression. "
5.	Cicatrix (Scar) 03/01/2011 - "In the brain injured and infused with LY-364947, fibrotic scar formation was suppressed and decreased numbers of reactive astrocytes occupied the lesion site. " 03/01/2011 - "To examine effects of the TGF-β signaling inhibition on formation of scar tissue and axonal regeneration, the small molecule inhibitor of type I TGF-β receptor kinase LY-364947 was continuously infused in the lesion site of mouse brain after a unilateral transection of the nigrostriatal dopaminergic pathway. "

Related Drugs and Biologics

1.	Collagen
2.	Gemcitabine
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Collagen Type II (Type II Collagen)
5.	Cadherins (E-Cadherin)
6.	Vimentin
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Phosphotransferases (Kinase)
9.	Bromodeoxyuridine (BrdU)