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CCT018159

structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - CCT018159: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - CCT018159: 3

Experts

1.	Hayes, Angela: 2 articles (03/2007 - 06/2006)
2.	McDonald, Edward: 2 articles (03/2007 - 06/2006)
3.	Workman, Paul: 2 articles (03/2007 - 06/2006)
4.	Daimon, Makoto: 1 article (08/2015)
5.	Ishigame, Noriko: 1 article (08/2015)
6.	Kageyama, Kazunori: 1 article (08/2015)
7.	Murasawa, Shingo: 1 article (08/2015)
8.	Niioka, Kanako: 1 article (08/2015)
9.	Sugiyama, Aya: 1 article (08/2015)
10.	Aherne, Wynne: 1 article (03/2007)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2015 - "Tumor weight in mice xenografted with AtT-20 cells and treated with CCT018159 was lower than in AtT-20-xenografted control mice. " 03/01/2007 - "CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis. " 03/01/2007 - "The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. " 08/01/2015 - "CCT018159 inhibits ACTH production and corticotroph tumor cell proliferation in vitro and in vivo." 03/01/2007 - "The molecular signature of HSP90 inhibition, comprising increased expression of HSP72 protein and depletion of ERBB2, CDK4, C-RAF, and mutant B-RAF, was shown by Western blotting and quantified by time-resolved fluorescent-Cellisa in human cancer cell lines treated with CCT018159. "
2.	Melanoma (Melanoma, Malignant) 03/01/2007 - "The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. "

Related Drugs and Biologics

1.	HSP72 Heat-Shock Proteins
2.	Messenger RNA (mRNA)
3.	Pro-Opiomelanocortin (Proopiomelanocortin)
4.	Heat-Shock Proteins (Heat-Shock Protein)
5.	Adrenocorticotropic Hormone (ACTH)
6.	tanespimycin (17AAG)

Related Therapies and Procedures

1.	Therapeutics