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N- hydroxy- 4- ((4- (phenylthio)phenyl)sulfonyl)- 1- (2- propynyl)- 4- piperidinecarboxamide (SC 276)
has antineoplastic activity; structure in first source
Also Known As:
SC 276
; SC-276; SC276 compound
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Hydroxylamines: 16
Hydroxamic Acids: 239
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide: 1
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxamic Acids: 239
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide: 1
Sulfur Compounds: 278
Sulfones: 534
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide: 1
Related Diseases
1.
Cardiomegaly (Heart Hypertrophy)
10/15/1987 - "
Lactate dehydrogenase activity increased significantly (P less than 0.01) in both TC (383 +/- 14 mumol/min/g wet wt) and TA (372 +/- 14 mumol/min/g wet wt) compared to SC (276 +/- 14 mumol/min/g wet wt), but not in TP versus SP. These data indicate that (1) beta-adrenergic blockade prevents training-induced cardiac hypertrophy; (2) beta-antagonists have little effect on the myocardial oxidative capacity; and (3) while the training induction of myocardial hexokinase is inhibited by both beta 1- and beta 1 + beta 2-antagonists, myocardium may increase its ability to utilize lactate during exercise with training despite beta 1-blockade.
"
Related Drugs and Biologics
1.
Lactic Acid (Lactate)
2.
Adrenergic Agents (Adrenergic Drugs)
3.
L-Lactate Dehydrogenase (Lactate Dehydrogenase)
4.
Hexokinase