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ISIS 3082

an ICAM-1 antisense oligonucleotide with NSAID activity

Also Known As:

5'-TGCATCCCCCAGGCCACCAT-3'; ISIS-3082; ISIS3082

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Oligodeoxyribonucleotides: 2217
        ISIS 3082: 3

Experts

1.	Bennink, Roel J: 1 article (09/2005)
2.	Boeckxstaens, Guy E: 1 article (09/2005)
3.	The, Frans O: 1 article (09/2005)
4.	de Jonge, Wouter J: 1 article (09/2005)
5.	van den Wijngaard, Rene M: 1 article (09/2005)

Related Diseases

1.	Ileus 09/01/2005 - "ISIS-3082 pretreatment prevents postoperative ileus in mice by reduction of manipulation-induced local intestinal muscle inflammation. " 09/01/2005 - "The aim of the current study was to evaluate the effect of ISIS-3082, a mouse-specific ICAM-1 antisense oligonucleotide, on postoperative ileus in mice. " 09/01/2005 - "The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice."
2.	Ulcerative Colitis 01/01/1999 - "A murine active antisense oligonucleotide, ISIS 3082, has been used for in vivo pharmacology studies and has anti-inflammatory activity in models of organ transplant rejection, ulcerative colitis, and collagen-induced arthritis at doses ranging from 0.03 to 5 mg/kg. The safety assessment for ISIS 2302 includes general toxicity studies up to 6 mo in duration in mice and monkeys, genetic toxicity studies, and reproductive/fertility studies. "
3.	Experimental Arthritis 01/01/1999 - "A murine active antisense oligonucleotide, ISIS 3082, has been used for in vivo pharmacology studies and has anti-inflammatory activity in models of organ transplant rejection, ulcerative colitis, and collagen-induced arthritis at doses ranging from 0.03 to 5 mg/kg. The safety assessment for ISIS 2302 includes general toxicity studies up to 6 mo in duration in mice and monkeys, genetic toxicity studies, and reproductive/fertility studies. "
4.	Inflammation (Inflammations) 09/01/2005 - "ISIS-3082 pretreatment prevents postoperative ileus in mice by reduction of manipulation-induced local intestinal muscle inflammation. " 09/01/2005 - "Similarly, ISIS-3082 (0.1-1 mg kg(-1)) and ICAM-1 antibodies, but not ISIS-8997 or higher doses of ISIS-3082 (3-10 mg kg(-1)), reduced manipulation-induced inflammation. "
5.	Colitis 02/01/1997 - "Prophylactic treatment of dextran sodium sulfate-treated mice with ISIS 3082 reduced the clinical signs of colitis in a dose-dependent manner, with maximal effects occurring at a dose of 1 mg/kg/day. " 02/01/1997 - "A murine-specific antisense oligonucleotide, ISIS 3082, was used to determine the role of ICAM-1 expression in the development of colitis. "

Related Drugs and Biologics

1.	Antisense Oligonucleotides
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	alicaforsen
4.	Dextrans (Dextran)
5.	Antibodies
6.	sodium sulfate (sodium bisulfate)