loureirin B

03/05/2022 - "Results showed that loureirin B prevented cardiac fibrosis and improved cardiac function in mice subjected to TAC. "
03/05/2022 - "This study investigated the effects of loureirin B on cardiac fibrosis and explored the underlying mechanisms. "
03/05/2022 - "Loureirin B ameliorated cardiac fibrosis and dysfunction both in vitro and in vivo probably through the Pin1/TGF-β1 signaling pathway."
03/05/2022 - "Loureirin B alleviates cardiac fibrosis by suppressing Pin1/TGF-β1 signaling."
05/01/2015 - "Taken together, this study demonstrates that loureirin B could downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved. "

01/01/2018 - "We investigated the activity of loureirin B against liver fibrosis and the underlying molecular mechanisms. "
01/01/2017 - "In vivo studies showed that loureirin B significantly prolonged the tail bleeding time and reduced the weight and size of arterial thrombus, reduced hydroxyproline level, and partly cured liver fibrosis in mice. "

01/01/2017 - "In vivo studies showed that loureirin B significantly prolonged the tail bleeding time and reduced the weight and size of arterial thrombus, reduced hydroxyproline level, and partly cured liver fibrosis in mice. "
01/01/2017 - "Taken together, the results revealed loureirin B as a PAI-1 inhibitor, adding a new pharmacological target for loureirin B and uncovering a novel mechanism underlying the antithrombotic property of Resina Draconis, which might be useful in the treatment of cardiovascular diseases such as thrombosis and fibrosis."

05/01/2015 - "Loureirin B, a major component in RDEE, has been supposed to be effective on the prevention and treatment of pathological scars. "
05/01/2015 - "Taken together, this study demonstrates that loureirin B could downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved. "
05/01/2015 - "In vivo rabbit ear scar model, loureirin B significantly improved the arrangement and deposition of collagen fibres, decreased protein levels of ColI, ColIII and α-SMA and suppressed myofibroblast differentiation and scar proliferative activity. "

11/05/2021 - "Loureirin B attenuates insulin resistance in HepG2 cells by regulating gluconeogenesis signaling pathway."
12/03/2022 - "Here, we show that Loureirin B (LB), a major flavonoid molecule extracted from Sanguis Draxonis, prevents diet-induced obesity and ameliorates concomitant metabolic abnormalities including fatty liver, insulin resistance and systemic inflammation in mice. "