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CMT-308

Also Known As:

9-amino-6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Tetracyclines: 1162
        CMT-308: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Tetracyclines: 1162
      - CMT-308: 2

Experts

1.	Goenka, Shilpi: 1 article (10/2020)
2.	Simon, Sanford R: 1 article (10/2020)
3.	Lokeshwar, Bal L: 1 article (02/2011)

Related Diseases

1.	Hyperpigmentation 10/13/2020 - "In summary, our results offer promise for therapeutic strategies to combat the effects of hyperpigmentation by use of CMT-308 at low micromolar concentrations." 10/13/2020 - "Based on its chemical structure, we hypothesized that CMT-308 could inhibit melanogenesis and might be a candidate for the treatment of skin hyperpigmentation disorders which occur due to unregulated melanin biosynthesis and/or transport. "
2.	Neoplasms (Cancer) 02/01/2011 - "CMT-3 and CMT-308 were significantly more potent than doxycycline or minocycline in inhibiting tumor cell-derived MMPs and inducing apoptosis in vitro and in vivo. "
3.	Melanoma (Melanoma, Malignant) 10/13/2020 - "Next, the effects of CMT-308 were tested in mammalian cell cultures using B16F10 mouse melanoma cells and further validated in darkly-pigmented human melanocytes (HEMn-DP). "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Minocycline (Cyclops)
3.	Melanins (Melanin)
4.	Doxycycline (Periostat)
5.	tetracycline CMT-3