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alpha- D- glucopyranosyl- (1- 2)- beta- D- galactopyranosyl- O- pyridinoline

structure in first source

Also Known As:

Glc-Gal-PYD

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Disaccharides: 990
      - alpha-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl-O-pyridinoline: 5
- Sugars: 11126
  - Disaccharides: 990
    - alpha-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl-O-pyridinoline: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - alpha-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl-O-pyridinoline: 5

Experts

1.	Delmas, P D: 4 articles (07/2006 - 03/2001)
2.	Garnero, P: 4 articles (07/2006 - 03/2001)
3.	Gineyts, E: 4 articles (07/2006 - 03/2001)
4.	Arden, N K: 1 article (07/2006)
5.	Cooper, C: 1 article (07/2006)
6.	Dennison, E M: 1 article (07/2006)
7.	Jordan, K M: 1 article (07/2006)
8.	Sayer, A A: 1 article (07/2006)
9.	Syddall, H E: 1 article (07/2006)
10.	Curtis, S P: 1 article (07/2004)

Related Diseases

1.	Knee Osteoarthritis 07/01/2004 - "The aim of this study was to evaluate the effect of ibuprofen on the urinary excretion of C-terminal crosslinking telopeptide of type II collagen (CTX-II) and urinary glucosyl galactosyl pyridinoline (Glc-Gal-PYD), two new molecular markers of cartilage and synovial tissue metabolism, respectively, in patients with knee osteoarthritis (OA). " 06/01/2001 - "To analyse the relations between the urinary levels of type II collagen C-telopeptide (CTX-II) and glucosyl-galactosyl pyridinoline (Glc-Gal-PYD)-two newly developed biochemical markers of type II collagen and synovial tissue destruction respectively-disease activity and the severity of joint destruction in patients with knee osteoarthritis (OA). "
2.	Inflammation (Inflammations) 01/01/2002 - "The association between baseline levels of urinary Glc-Gal-PYD and progression of joint erosion was independent of the severity of radiologic damage and inflammation at baseline. " 01/01/2002 - "To evaluate whether measurements of urinary glucosyl-galactosyl-pyridinoline (Glc-Gal-PYD) and urinary C-terminal crosslinking telopeptide of type II collagen (CTX-II), 2 new markers of destruction of the synovium and cartilage collagen breakdown, respectively, are associated with the progression of joint damage in patients with early rheumatoid arthritis (RA), and to compare this association with that with serum matrix metalloproteinase 3 (MMP-3), a proteinase expressed by synovial tissue and chondrocytes, and that with serum C-reactive protein (CRP), an index of systemic inflammation. " 06/01/2001 - "The following biochemical markers were measured in a group of 67 patients with knee OA (mean age 64 years, median disease duration eight years ) and in 67 healthy controls: for bone, serum osteocalcin, serum and urinary C-telopeptide of type I collagen (CTX-I); for cartilage, urinary CTX-II, serum cartilage oligomeric matrix protein (COMP), and serum human cartilage glycoprotein 39 (YKL-40); for synovium, urinary Glc-Gal-PYD, serum type III collagen N-propeptide (PIIINP), serum hyaluronic acid (HA); and for inflammation, serum C reactive protein. "
3.	Rheumatoid Arthritis 03/01/2001 - "The urinary level of Glc-Gal-PYD was increased by 109% in patients with rheumatoid arthritis (RA) compared with healthy adults, but was normal in patients with Paget's disease of bone. " 01/01/2002 - "To evaluate whether measurements of urinary glucosyl-galactosyl-pyridinoline (Glc-Gal-PYD) and urinary C-terminal crosslinking telopeptide of type II collagen (CTX-II), 2 new markers of destruction of the synovium and cartilage collagen breakdown, respectively, are associated with the progression of joint damage in patients with early rheumatoid arthritis (RA), and to compare this association with that with serum matrix metalloproteinase 3 (MMP-3), a proteinase expressed by synovial tissue and chondrocytes, and that with serum C-reactive protein (CRP), an index of systemic inflammation. "
4.	Osteophyte 07/01/2006 - "A significant positive association was also found between urinary CTX-II and urinary Glc-Gal-Pyd and the severity of K&L grade, joint space narrowing, and osteophytes scores, which persisted after adjustment for age and BMI. "
5.	Osteitis Deformans (Paget's Disease of Bone) 03/01/2001 - "The urinary level of Glc-Gal-PYD was increased by 109% in patients with rheumatoid arthritis (RA) compared with healthy adults, but was normal in patients with Paget's disease of bone. "

Related Drugs and Biologics

1.	Collagen Type II (Type II Collagen)
2.	pyridinoline
3.	Ibuprofen (Motrin)
4.	C-Reactive Protein
5.	Cartilage Oligomeric Matrix Protein
6.	Collagen Type III (Type III Collagen)
7.	Collagen Type I (Type I Collagen)
8.	Matrix Metalloproteinase 3 (Stromelysin 1)
9.	Osteocalcin
10.	Biomarkers (Surrogate Marker)