(6,7- dimethoxy- 2,4- dihydroindeno(1,2- c)pyrazol- 3- yl)(3- fluorophenyl)amine

a PDGF receptor tyrosine kinase inhibitor; a PDGF-BB antagonist with both antiangiogenic and antineoplastic activites; structure in first source

Also Known As:

J101 compound; JNJ 10198409; JNJ-10198409; JNJ10198409; RWJ-540973

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Carballo-Santana, Mar: 1 article (09/2018)
2.	Carrasco-Garcia, Estefania: 1 article (09/2018)
3.	Fuentes-Baile, Maria: 1 article (09/2018)
4.	García-Morales, Pilar: 1 article (09/2018)
5.	Martinez-Lacaci, Isabel: 1 article (09/2018)
6.	Mayor-López, Leticia: 1 article (09/2018)
7.	Rodriguez-Lescure, Álvaro: 1 article (09/2018)
8.	Saceda, Miguel: 1 article (09/2018)
9.	Tristante, Elena: 1 article (09/2018)
10.	Ventero Martin, Maria Paz: 1 article (09/2018)

1.	Neoplasms (Cancer) 09/06/2018 - "We have studied the effects of the PDGFR inhibitor JNJ-10198409 (JNJ) and the IGF-1R inhibitor picropodophyllin (PPP) in glioblastoma cell lines as well as in primary cultures derived from patients affected by this type of tumor. " 08/01/2005 - "Hence, we investigated the in vivo pharmacodynamic activity of JNJ-10198409, a relatively selective inhibitor of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK), in tumor tissues after administering the compound orally in a nude mouse xenograft model of human LoVo colon cancer. "
2.	Glioblastoma (Glioblastoma Multiforme) 09/06/2018 - "We have studied the effects of the PDGFR inhibitor JNJ-10198409 (JNJ) and the IGF-1R inhibitor picropodophyllin (PPP) in glioblastoma cell lines as well as in primary cultures derived from patients affected by this type of tumor. "
3.	Colonic Neoplasms (Colon Cancer) 08/01/2005 - "Hence, we investigated the in vivo pharmacodynamic activity of JNJ-10198409, a relatively selective inhibitor of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK), in tumor tissues after administering the compound orally in a nude mouse xenograft model of human LoVo colon cancer. "

1.	picropodophyllin
2.	PDGF receptor tyrosine kinase