CGC-11144

Polyamine analogue inhibit tumor growth in vitro and in vivo

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Akiyama, Hideo: 2 articles (11/2006 - 09/2005)
2.	Aslam, Sadia: 2 articles (11/2006 - 09/2005)
3.	Campochiaro, Peter A: 2 articles (11/2006 - 09/2005)
4.	Gong, Yuan Yuan: 2 articles (11/2006 - 09/2005)
5.	Hackett, Sean F: 2 articles (11/2006 - 09/2005)
6.	Kachi, Shu: 2 articles (11/2006 - 09/2005)
7.	Lima e Silva, Raquel: 2 articles (11/2006 - 09/2005)
8.	Marton, Laurence J: 2 articles (11/2006 - 09/2005)
9.	Hatara, Maria Christina: 1 article (11/2006)
10.	Khu, Naw Htee: 1 article (11/2006)

1.	Choroidal Neovascularization 09/01/2005 - "This study was conducted to investigate the effect of the decamines CGC-11144 and CGC-11150 in a mouse model of choroidal neovascularization (CNV). " 11/01/2006 - "Periocular injections of the polyamine analog CGC-11144 three times a week causes regression of choroidal neovascularization. " 11/01/2006 - "A single periocular injection of 200 microg of CGC-11144, 2 mg of CGC-11047, or 1.5 mg of CGC-11093 caused significant suppression and regression of laser-induced choroidal neovascularization. "
2.	Rupture 09/01/2005 - "Intravitreous injection of 20 microg CGC-11144 or CGC-11150 on days 0 and 7 after rupture of Bruch's membrane resulted in a approximately 40% reduction in the area of CNV, with a similar reduction after periocular injections of 0.2 mg CGC-11144 three times a week for 2 weeks. " 09/01/2005 - "Mice with laser-induced rupture of Bruch's membrane were given intraperitoneal, intravitreous, or periocular injection of CGC-11144, CGC-11150, or vehicle, and after 14 days, they were perfused with fluorescein-labeled dextran, and the area of CNV was measured on choroidal flatmounts by image analysis. "