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Dhvar-5

antimicrobial synthetic peptide based on the amino acid composition of histatin-5

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Stallmann, Hein P: 2 articles (12/2005 - 12/2004)
2.	Wuisman, Paul I J M: 2 articles (12/2005 - 12/2004)
3.	Lyaruu, D M: 2 articles (12/2004 - 06/2003)
4.	Amerongen, Arie V Nieuw: 1 article (12/2005)
5.	Bronckers, Antonius L J J: 1 article (12/2005)
6.	Brouwer, Carlo P J M: 1 article (12/2005)
7.	Faber, Chris: 1 article (12/2005)
8.	de Blieck-Hogervorst, Jolanda M A: 1 article (12/2005)
9.	Faber, Christopher: 1 article (12/2004)
10.	Hoogendoorn, Roel J W: 1 article (12/2004)

Related Diseases

1.	Osteomyelitis 12/01/2004 - "The aim of the study was to investigate the efficacy of the antimicrobial peptide Dhvar-5 in a prophylactic, methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis model. " 12/01/2004 - "In vivo comparison of Dhvar-5 and gentamicin in an MRSA osteomyelitis prevention model." 06/01/2003 - "In order to develop a new local treatment using Dhvar-5 for osteomyelitis, we investigated its release from PMMA beads and its antimicrobial activity against a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA) before and after release from PMMA beads. "
2.	Infections 12/01/2004 - "We conclude that both the gentamicin beads and the Dhvar-5 beads were only partially effective at preventing MRSA infection in this model."
3.	Hemolysis 12/01/2005 - "Both hLF1-11 and Dhvar-5 dose-dependently killed all bacterial strains, starting at concentrations of 6 microg/mL. hLF1-11 had no effect on mammalian cells at concentrations up to 400 microg/mL, but Dhvar-5 induced significant hemolysis (37% at 200 microg/mL) and bone cell death (70% at 400 microg/mL). "

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	Gentamicins (Gentamicin)
3.	Polymethyl Methacrylate (Sol)