(4- methoxy- phenyl)- (6- methoxy- quinazolin- 4- yl)- amine HCl

04/01/2005 - "LY456236 reduced operant responding at 30 mg/kg. Both mGluR5 and mGluR1 antagonists are effective in models of pain and anxiety. "
04/01/2005 - "The mGluR5 antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP), and the mGluR1 antagonist, (4-methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine HCl (LY456236), were tested in models of pain [mouse formalin test, rat spinal nerve ligation (SNL)] and anxiety [Vogel conflict, conditioned lick suppression (CLS)], and their efficacious effects were compared to any associated side effects. "

01/01/2005 - "In addition, LY456236 produced a dose-related increase in the stimulus intensity required to produce generalized seizures. "
01/01/2005 - "In amygdala-kindled male Sprague-Dawley rats, LY456236 produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. "
01/01/2005 - "In male CF1 mice, LY456236 produced a dose-related inhibition of tonic extensor seizures in the threshold electroshock model, and limbic seizures in the 6-Hz focal seizure model. "
01/01/2005 - "In male and female DBA/2 mice, LY456236 produced a dose-related inhibition of sound-induced clonic-tonic seizures. "
05/01/2005 - "LY456236 blocked the seizures produced by 30 nmol but not by 400 nmol; dantrolene was ineffective in blocking seizures produced by either dose. "

04/01/2005 - "However, only LY456236 completely reversed the allodynia. "
04/01/2005 - "The systemic administration of MPEP, MTEP, and LY456236 reduced hyperalgesia induced by formalin and mechanical allodynia following SNL. "

01/01/2005 - "Taken together, the present results support the conclusion that mGlu1 receptor antagonists such as LY456236 may have clinical utility in the treatment of epilepsy and other seizure disorders."