HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

N- methoxy- 6- (5- (4- (N- methoxyamidino)phenyl)furan- 2- yl)nicotinamidine

prodrug of DB-820; structure in first source

Also Known As:

DB 844; DB-844; DB844

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Benzamidines: 5
    - N-methoxy-6-(5-(4-(N-methoxyamidino)phenyl)furan-2-yl)nicotinamidine: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - N-methoxy-6-(5-(4-(N-methoxyamidino)phenyl)furan-2-yl)nicotinamidine: 3

Experts

1.	Boykin, David W: 2 articles (01/2014 - 01/2012)
2.	Tidwell, Richard R: 2 articles (01/2014 - 01/2012)
3.	Ansede, John H: 1 article (01/2014)
4.	Bridges, Arlene S: 1 article (01/2014)
5.	Hall, James Edwin: 1 article (01/2014)
6.	Ismail, Mohamed A: 1 article (01/2014)
7.	Ju, Wujian: 1 article (01/2014)
8.	Stephens, Chad E: 1 article (01/2014)
9.	Voyksner, Robert D: 1 article (01/2014)
10.	Wang, Michael Zhuo: 1 article (01/2014)

Related Diseases

1.	African Trypanosomiasis (Nagana) 01/01/2012 - "Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis." 01/01/2014 - "DB844 (CPD-594-12), N-methoxy-6-{5-[4-(N-methoxyamidino)phenyl]-furan-2-yl}-nicotinamidine, is an oral prodrug that has shown promising efficacy in both mouse and monkey models of second stage human African trypanosomiasis. " 03/01/2005 - "The dimethoxyamidine prodrug of DB820, N-methoxy-6-{5-[4-(N-methoxyamidino)phenyl]-furan-2-yl}-nicotinamidine (DB844), has potent oral activity in mouse models of both early-stage and CNS African trypanosomiasis. "
2.	Infections 01/01/2012 - "DB844 was administered orally to vervet monkeys, beginning 28 days post infection (DPI) with Trypanosoma brucei rhodesiense KETRI 2537. "

Related Drugs and Biologics

1.	Prodrugs
2.	furan
3.	pafuramidine