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PCI 2000

a sapphyrin derivative with antineoplastic activity; structure in first source

Also Known As:

PCI-2000; PCI2000

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Boswell, Garry: 2 articles (11/2006 - 06/2005)
2.	Chen, Jun: 2 articles (11/2006 - 06/2005)
3.	Cortez, Cecilia: 2 articles (11/2006 - 06/2005)
4.	Lecane, Philip: 2 articles (11/2006 - 06/2005)
5.	Magda, Darren: 2 articles (11/2006 - 06/2005)
6.	Miller, Richard: 2 articles (11/2006 - 06/2005)
7.	Naumovski, Louie: 2 articles (11/2006 - 06/2005)
8.	Ramos, Jason: 2 articles (11/2006 - 06/2005)
9.	Sirisawad, Mint: 2 articles (11/2006 - 06/2005)
10.	Thiemann, Patti: 2 articles (11/2006 - 06/2005)

Related Diseases

1.

Neoplasms (Cancer)

06/01/2005 - "PCI-2010 showed less toxicity in mice than PCI-2000 and was active in slowing the growth of Ramos and HL-60 tumor xenografts in nude mice. "
11/01/2006 - "Ex vivo analysis of sapphyrin-injected animals revealed that PCI-2050 preferentially localized to tumor, whereas PCI-2000 distributed into normal tissues rather than tumor. "
06/01/2005 - "PCI-2000 triggers an apoptotic pathway in these tumor cells as shown by release of cytochrome c from mitochondria; activation of caspases 9, 8, and 3; cleavage of the caspase substrate poly(ADP-ribose) polymerase; and Annexin V binding. "

Related Drugs and Biologics

1.	Cytochromes c (Cytochrome c)
2.	Caspases
3.	Annexin A5
4.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
5.	PCI 2050
6.	PCI 2010
7.	sapphyrin