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SB 399885

5-HT6 receptor antagonist

Also Known As:

SB-399885; SB399885

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - SB 399885: 7
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - SB 399885: 7
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - SB 399885: 7

Experts

1.	Aparicio-Nava, L: 1 article (01/2019)
2.	Gonzalez, R: 1 article (01/2019)
3.	Liy-Salmeron, G: 1 article (01/2019)
4.	Meneses, A: 1 article (01/2019)
5.	Tellez, R: 1 article (01/2019)
6.	Fairclough, Lucy C: 1 article (09/2018)
7.	Fowler, Maxine: 1 article (09/2018)
8.	King, Madeleine V: 1 article (09/2018)
9.	Negm, Ola H: 1 article (09/2018)
10.	Shortall, Sinead E: 1 article (09/2018)

Related Diseases

1.	Amnesia (Dissociative Amnesia) 01/01/2019 - "Moreover, intrahippocampal inactive doses of EMD386088 (5 μg) plus SB-399885 (0.5 μg) did not affect STM and LTM; however, partially or completely prevented the scopolamine or dizocilpine-induced amnesia. " 07/01/2005 - "Moreover, modeling the potential therapeutic benefits of 5-HT6 receptor blockade, acute or repeated administration of SB-399885, at 10 mg/kg reversed memory deficits produced by scopolamine or dizocilpine, and SB-357134 (3 and 10 mg/kg) prevented amnesia and even improved performance. "
2.	Memory Disorders (Memory Loss) 07/01/2005 - "Moreover, modeling the potential therapeutic benefits of 5-HT6 receptor blockade, acute or repeated administration of SB-399885, at 10 mg/kg reversed memory deficits produced by scopolamine or dizocilpine, and SB-357134 (3 and 10 mg/kg) prevented amnesia and even improved performance. "
3.	Traumatic Stress Disorders (Traumatic Stress Disorder) 08/01/2015 - "Therapeutic Potential of 5-HT6 Antagonist SB399885 in Traumatic Stress Disorder."
4.	Seizures (Absence Seizure) 01/01/2015 - "We found that HTR6 expression was upregulated in both human tissues and the pilocarpine rat model, and that SB-399885 could suppress epileptic seizures and mTOR activity in epileptic seizures. "
5.	Schizophrenia (Dementia Praecox) 09/01/2018 - "Characterization of Behavioral, Signaling and Cytokine Alterations in a Rat Neurodevelopmental Model for Schizophrenia, and Their Reversal by the 5-HT6 Receptor Antagonist SB-399885."

Related Drugs and Biologics

1.	serotonin 6 receptor
2.	Dizocilpine Maleate (Dizocilpine)
3.	Scopolamine (Hyoscine)
4.	Dihydrotachysterol (AT 10)
5.	N- (2,5- dibromo- 3- fluorophenyl)- 4- methoxy- 3- piperazin- 1- ylbenzenesulfonamide
6.	Amyloid beta-Peptides
7.	Cytokines
8.	Serotonin (5 Hydroxytryptamine)
9.	Pilocarpine (Ocusert)
10.	Ligands