INO-4995

a synthetic analog of the intracellular signaling molecule, D-myo-inositol 3,4,5,6-tetrakisphosphate, inhibits Na(+) and fluid absorption across CF airway epithelia, thus alleviating this critical pathology; structure in first source

Also Known As:

2-O-butyryl-1-O-octyl-myo-Inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Traynor-Kaplan, Alexis E: 2 articles (01/2013 - 01/2010)
2.	Amaral, Margarida D: 1 article (01/2013)
3.	Faria, Diana: 1 article (01/2013)
4.	Fragata, José I: 1 article (01/2013)
5.	Kongsuphol, Patthara: 1 article (01/2013)
6.	Kunzelmann, Karl: 1 article (01/2013)
7.	Palma, Marta: 1 article (01/2013)
8.	Schreiber, Rainer: 1 article (01/2013)
9.	Sousa, Marisa: 1 article (01/2013)
10.	Tian, Yuemin: 1 article (01/2013)

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis) 01/01/2010 - "INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia." 01/01/2013 - "The potentiating effect of INO-4995 on transient ATP-activated TMEM16A-currents in cystic fibrosis (CF) airways was twice of that observed in non-CF airways. "
2.	Lung Diseases (Lung Disease) 01/01/2013 - "INO-4995 may be useful for the treatment of CF lung disease."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)