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vacuolin-1

inhibits Ca2-dependent lysosomal exocytosis

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - vacuolin-1: 10

Experts

1.	Case, James Brett: 2 articles (06/2020 - 01/2020)
2.	Chen, Rita E: 2 articles (06/2020 - 01/2020)
3.	Chou, Yi-Ying: 2 articles (06/2020 - 01/2020)
4.	Cureton, David: 2 articles (06/2020 - 01/2020)
5.	Diamond, Michael S: 2 articles (06/2020 - 01/2020)
6.	Kang, Yuan-Lin: 2 articles (06/2020 - 01/2020)
7.	Kirchhausen, Tom: 2 articles (06/2020 - 01/2020)
8.	Liu, Zhuoming: 2 articles (06/2020 - 01/2020)
9.	Rothlauf, Paul W: 2 articles (06/2020 - 01/2020)
10.	Soh, Timothy K: 2 articles (06/2020 - 01/2020)

Related Diseases

1.	Glioma (Gliomas) 01/01/2012 - "In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on lysosome exocytosis were studied to determine their effect on glioma cell migration and invasion. "
2.	Glioblastoma (Glioblastoma Multiforme) 02/01/2018 - "In this study we assessed the effects of MOPIPP, a novel indole-based chalcone, and vacuolin-1, a distinct triazine-based compound, on exosome production in cultured glioblastoma and 293T cells. "
3.	Leukemia 11/03/2022 - "Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differentiation steps." 08/01/2009 - "Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis. "
4.	Infections 06/15/2020 - "We describe here potent inhibitory effects on content release and infection by chimeric VSV containing the envelope proteins of Zaire ebolavirus (VSV-ZEBOV) or SARS-CoV-2 (VSV-SARS-CoV-2) elicited by Apilimod and Vacuolin-1, small molecule inhibitors of the main endosomal Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase, PIKfyve. " 01/01/2020 - "We describe here potent inhibitory effects on content release and infection by chimeric vesicular stomatitis virus (VSV) containing the envelope proteins of Zaire ebolavirus (VSV-ZEBOV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (VSV-SARS-CoV-2) elicited by Apilimod and Vacuolin-1, small-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve. "
5.	Vesicular Stomatitis 01/01/2020 - "We describe here potent inhibitory effects on content release and infection by chimeric vesicular stomatitis virus (VSV) containing the envelope proteins of Zaire ebolavirus (VSV-ZEBOV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (VSV-SARS-CoV-2) elicited by Apilimod and Vacuolin-1, small-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve. "

Related Drugs and Biologics

1.	Triazines
2.	Chalcone (Benzalacetophenone)
3.	indole
4.	Proteins (Proteins, Gene)
5.	Phosphatidylinositols (Phosphatidylinositol)
6.	Phosphates (Orthophosphate)
7.	apilimod
8.	Vacuolar Proton-Translocating ATPases (V-Type ATPase)
9.	Sirolimus (Rapamycin)
10.	IgE Receptors (Fc epsilon RI)