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2- phenyl- 4- (3- pyridin- 2- yl- 1H- pyrazol- 4- yl)pyridine

inhibits the receptor ALK5; structure in first source

Also Known As:

GW 6604; GW-6604; GW6604

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine: 2
  - Pyridines: 88
    - 2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine: 2

Experts

1.	Huet, Stephane: 2 articles (03/2006 - 05/2005)
2.	de Gouville, Anne-Charlotte: 2 articles (03/2006 - 05/2005)
3.	Boullay, Valerie: 1 article (05/2005)
4.	Brusq, Jean-Marie: 1 article (05/2005)
5.	Gauthier, Jean-Michel: 1 article (05/2005)
6.	Gellibert, Françoise: 1 article (05/2005)
7.	Krysa, Gael: 1 article (05/2005)
8.	Laroze, Alain: 1 article (05/2005)
9.	Loriolle, Florence: 1 article (05/2005)
10.	Papworth, Stephen A: 1 article (05/2005)

Related Diseases

1.	Liver Diseases (Liver Disease) 05/01/2005 - "In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. " 05/01/2005 - "The identification of GW6604 (2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine), an ALK5 inhibitor, allowed us to evaluate the therapeutic potential of inhibiting TGF-beta pathway in different models of liver disease. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 03/01/2006 - "Thus far, there is only one ALK5 inhibitor (GW6604) for which activity in models of liver fibrosis has been described, showing clear antifibrotic effects resulting in liver function improvement. "
3.	Fibrosis (Cirrhosis) 05/01/2005 - "In a chronic model of DMN-induced fibrosis where DMN was administered for 6 weeks and GW6604 dosed for the last 3 weeks (80 mg kg(-1) p.o., b.i.d.), mortality was prevented and DMN-induced elevations of mRNA encoding for collagen IA1, IA2, III, TIMP-1 and TGF-beta were reduced by 50-75%. "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-1
2.	Transforming Growth Factor beta (TGF-beta)
3.	Messenger RNA (mRNA)
4.	Collagen