HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2,3- dimethyl- 6- phenyl- 12H- (1,3)dioxolo(4,5- h)imidazo(1,2- c)(2,3)benzodiazepine

a neuroprotective agent; structure in first source

Also Known As:

ZK 187638; ZK-187638; ZK187638

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - 2,3-dimethyl-6-phenyl-12H-(1,3)dioxolo(4,5-h)imidazo(1,2-c)(2,3)benzodiazepine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        2,3-dimethyl-6-phenyl-12H-(1,3)dioxolo(4,5-h)imidazo(1,2-c)(2,3)benzodiazepine: 2

Experts

1.	Elger, Bernd: 2 articles (10/2006 - 04/2006)
2.	Bonomi, Marco: 1 article (10/2006)
3.	Caccia, Silvio: 1 article (10/2006)
4.	Carvelli, Lucia: 1 article (10/2006)
5.	Colovic, Milena: 1 article (10/2006)
6.	Fracasso, Claudia: 1 article (10/2006)
7.	Guiso, Giovanna: 1 article (10/2006)
8.	Mennini, Tiziana: 1 article (10/2006)
9.	Schneider, Matthias: 1 article (10/2006)
10.	Winter, Eric: 1 article (10/2006)

Related Diseases

1.	Stroke (Strokes) 04/26/2006 - "Since cerebral glutamate levels are elevated for many hours in progressing stroke, we investigated the novel AMPA glutamate receptor antagonist ZK 187638 in rodent models of stroke using up to 12 h delays in the start of therapy after permanent occlusion of the middle cerebral artery (MCA). "
2.	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 10/01/2006 - "Optimized synthesis of AMPA receptor antagonist ZK 187638 and neurobehavioral activity in a mouse model of neuronal ceroid lipofuscinosis."
3.	Infarction (Infarctions) 04/26/2006 - "Dose-dependent decreases of total infarct volume (up to 42%) were measured in mice given the first injection of ZK 187638 6 h after permanent MCA occlusion. " 04/26/2006 - "In rats, ZK 187638 reduced total infarct volume by 43% and 33% when therapy was started immediately or with a delay of 6 h, respectively, but no effect was observed after a 12 h delay. "
4.	Brain Ischemia (Cerebral Ischemia) 04/26/2006 - "In conclusion, the AMPA receptor antagonist ZK 187638 has a therapeutic time window of at least 6 h after permanent focal cerebral ischemia in rodents."

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	Glutamic Acid (Glutamate)
3.	Excitatory Amino Acid Antagonists
4.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)

Related Therapies and Procedures

1.	Therapeutics