(5- (2- methoxy- 5- chloro- 5- phenyl)furan- 2- ylcarbonyl)guanidine

KR-32570 possesses potent cardioprotective effects in perfused rat hearts, and its effects may be mediated by inhibition of NHE-1, preservation of high-energy phosphates, and inhibition of lipid peroxidation

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Networked: 5 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Lee, Sunkyung: 3 articles (11/2005 - 03/2005)
2.	Yi, Kyu Yang: 3 articles (11/2005 - 03/2005)
3.	Kim, Hyojin: 2 articles (04/2007 - 01/2006)
4.	Kim, Hyunmi: 2 articles (04/2007 - 01/2006)
5.	Lee, Hye Suk: 2 articles (04/2007 - 01/2006)
6.	Liu, Kwang-Hyeon: 2 articles (04/2007 - 01/2006)
7.	Shin, Jae-Gook: 2 articles (04/2007 - 01/2006)
8.	Lee, Byung Ho: 2 articles (10/2005 - 03/2005)
9.	Lee, Sunghou: 2 articles (10/2005 - 03/2005)
10.	Yoo, Sung-eun: 2 articles (10/2005 - 03/2005)

Related Diseases

1.	Ischemia 03/28/2005 - "Effects of KR-32570, a new Na+/H+ exchanger inhibitor, on functional and metabolic impairments produced by global ischemia and reperfusion in the perfused rat heart." 10/31/2005 - "Taken together, these results indicate that KR-32570 significantly reduced the myocardial infarction and incidence of arrhythmias induced by ischemia and reperfusion in rats and dogs, without affecting hemodynamic profiles. " 03/28/2005 - "KR-32570 (1-10 microM) significantly decreased the concentration of 8-iso-prostaglandin F(2 alpha), a reliable marker for oxidant stress, in perfusates from rat hearts subjected to ischemia and reperfusion. " 03/28/2005 - "In isolated perfused rat hearts subjected to 30-min ischemia/30-min reperfusion, KR-32570 (1-10 microM) significantly and concentration dependently improved cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release. " 10/31/2005 - "Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion."
2.	Ventricular Premature Complexes (Premature Ventricular Contraction) 10/31/2005 - "KR-32570 dose-dependently decreased the incidence of premature ventricular contraction, ventricular tachycardia or ventricular fibrillation induced by ischemia and reperfusion in rats. "
3.	Ventricular Tachycardia 10/31/2005 - "KR-32570 dose-dependently decreased the incidence of premature ventricular contraction, ventricular tachycardia or ventricular fibrillation induced by ischemia and reperfusion in rats. "
4.	Ventricular Fibrillation 10/31/2005 - "KR-32570 dose-dependently decreased the incidence of premature ventricular contraction, ventricular tachycardia or ventricular fibrillation induced by ischemia and reperfusion in rats. "
5.	Contracture 03/28/2005 - "In isolated perfused rat hearts subjected to 30-min ischemia/30-min reperfusion, KR-32570 (1-10 microM) significantly and concentration dependently improved cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release. "

Related Drugs and Biologics

1.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
2.	Guanidine (Guanidine Nitrate)
3.	furan
4.	Cytochromes c (Cytochrome c)
5.	Protein Isoforms (Isoforms)
6.	Troponin I
7.	Sodium-Hydrogen Exchangers
8.	Oxidants (Oxidizing Agents)
9.	Isoenzymes
10.	Creatine Kinase (Creatine Phosphokinase)