r- 1,t- 2,3,c- 4- tetrahydroxy- 1,2,3,4- tetrahydrophenanthrene

urinary metabolite of phenanthrene as a biomarker of polycyclic aromatic hydrocarbon metabolic activation in workers exposed to residual oil fly ash

Also Known As:

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carmella, Steven G: 2 articles (11/2011 - 01/2009)
2.	Hecht, Stephen S: 2 articles (11/2011 - 01/2009)
3.	Chen, Menglan: 1 article (11/2011)
4.	Davis, Andrew B: 1 article (11/2011)
5.	Gao, Yu-Tang: 1 article (11/2011)
6.	Han, Shaomei: 1 article (11/2011)
7.	Moy, Kristin A: 1 article (11/2011)
8.	Murphy, Sharon E: 1 article (11/2011)
9.	Nelson, Heather H: 1 article (11/2011)
10.	Tao, Li: 1 article (11/2011)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/2009 - "In a case-control study nested in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we randomly selected 100 lung cancer cases and 100 controls who smoked at baseline and analyzed their baseline serum for total NNAL, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbon exposure and metabolic activation. " 11/01/2011 - "In this study, we quantified prediagnostic urinary levels of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a validated biomarker of PAH uptake and metabolism, as well as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine and its glucuronides (total cotinine), validated biomarkers of uptake of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and nicotine, respectively, in relation to lung cancer risk among current smokers in a nested case-control study within a cohort of 18,244 Chinese men in Shanghai, China. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2009 - "In a case-control study nested in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we randomly selected 100 lung cancer cases and 100 controls who smoked at baseline and analyzed their baseline serum for total NNAL, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbon exposure and metabolic activation. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Cotinine
3.	Glucuronides
4.	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
5.	Nicotine
6.	4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- ol
7.	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanone