claudin 16

Also Known As:

CLDN16 protein, human; Cldn16 protein, mouse; Cldn16 protein, rat; PCLN1 protein, human; PCLN1 protein, mouse; Pcln1 protein, rat; claudin 16 protein, human; claudin 16 protein, mouse; claudin 16 protein, rat; claudin-16; paracellin-1 protein, human; paracellin-1 protein, mouse; paracellin-1 protein, rat

Networked: 55 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Tight Junction Proteins: 1698
      - Claudins: 1049
        claudin 16: 55

Experts

1.	Hou, Jianghui: 10 articles (01/2019 - 06/2007)
2.	Müller, Dominik: 6 articles (01/2018 - 12/2003)
3.	Goodenough, Daniel A: 6 articles (09/2010 - 06/2007)
4.	Bleich, Markus: 5 articles (01/2019 - 06/2007)
5.	Hunziker, Walter: 5 articles (02/2015 - 12/2003)
6.	Himmerkus, Nina: 4 articles (01/2019 - 12/2008)
7.	Konrad, Martin: 4 articles (03/2013 - 08/2006)
8.	Claverie-Martin, Felix: 3 articles (03/2019 - 12/2003)
9.	Renigunta, Aparna: 3 articles (01/2019 - 02/2008)
10.	Jiang, Wen G: 3 articles (01/2015 - 09/2008)

Related Diseases

1.	Hypercalciuria 07/01/2006 - "The latter has been exemplified by the discovery of claudin 16 (paracellin-1) as the gene product responsible for the hypomagnesaemia with hypercalciuria syndrome. " 12/01/2003 - "Screening a cohort of 11 families with idiopathic hypercalciuria identified a novel homozygous mutation in the claudin 16 gene in two families. " 12/01/2003 - "A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargeting." 05/01/2022 - "The claudin-16 or -19 mutation causes familial hypomagnesemia with hypercalciuria and nephrocalcinosis. " 03/20/2019 - "Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis."
2.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2022 - "The patient was subsequently diagnosed with a renal carcinoma that expressed a high level of claudin-16 mRNA. " 01/01/2015 - "The current study investigated the expression of claudins 1, 5 and 16 in human clear cell renal cell carcinoma (CCRCC) and the impact of claudin-16 on kidney cancer cells. "
3.	Kidney Neoplasms (Kidney Cancer) 01/01/2015 - "In conclusion, the present study showed that kidney tissue and CCRCC tissues highly expressed claudin-16 and claudin-1, and that claudin-16 has a profound impact on barrier function and cell adhesion in kidney cancer cells. " 01/01/2015 - "The current study investigated the expression of claudins 1, 5 and 16 in human clear cell renal cell carcinoma (CCRCC) and the impact of claudin-16 on kidney cancer cells. "
4.	Acidosis 01/01/2021 - "We conclude that in metabolic acidosis, claudin-16 and claudin-19 in the thick ascending limb are down-regulated to produce hypercalciuria and hypermagnesiuria via the calcium-sensing receptor.NEW & NOTEWORTHY This study found that the thick ascending limb of Henle's loop is involved in the mechanisms of hypercalciuria and hypermagnesiuria in metabolic acidosis. " 01/01/2021 - "Specifically, expression of claudin-16/19 and claudin-14 was altered via up-regulation of calcium-sensing receptor in NH4Cl-induced metabolic acidosis. "
5.	Nephrocalcinosis 01/01/2013 - "Mutations in claudin-16 and -19 cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. " 05/01/2022 - "The claudin-16 or -19 mutation causes familial hypomagnesemia with hypercalciuria and nephrocalcinosis. " 03/20/2019 - "Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis." 01/01/2019 - "Atypical presentation of familial hypomagnesemia with hypercalciuria and nephrocalcinosis in a patient with a new claudin-16 gene mutation." 01/01/2018 - "Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. "

Related Drugs and Biologics

1.	Claudins
2.	Calcium-Sensing Receptors
3.	Claudin-1
4.	Tight Junction Proteins
5.	Magnesium
6.	Calcium
7.	Proteins (Proteins, Gene)
8.	claudin 14
9.	Calcitriol Receptors (Calcitriol Receptor)
10.	Adenylyl Cyclases (Adenylyl Cyclase)

Related Therapies and Procedures

1.	Therapeutics