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FRP-170

radiopharmaceutical; structure in first source

Also Known As:

(18F)1-(2-fluoro-1-(hydroxymethyl)ethoxy)methyl-2-nitroimidazole; (18F)FRP-170

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - FRP-170: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        FRP-170: 2

Experts

1.	Iwata, Ren: 2 articles (08/2010 - 08/2008)
2.	Higano, Shuichi: 1 article (08/2010)
3.	Kanamori, Masayuki: 1 article (08/2010)
4.	Kumabe, Toshihiro: 1 article (08/2010)
5.	Saito, Ryuta: 1 article (08/2010)
6.	Shibahara, Ichiyo: 1 article (08/2010)
7.	Sonoda, Yukihiko: 1 article (08/2010)
8.	Takai, Yoshihiro: 1 article (08/2010)
9.	Takanami, Kentaro: 1 article (08/2010)
10.	Tominaga, Teiji: 1 article (08/2010)

Related Diseases

1.	Hypoxia (Hypoxemia) 08/01/2010 - "Imaging with FRP-170 PET seemed to be more sensitive for detecting hypoxia than identifying the lactate peak on proton MR spectroscopy. " 08/01/2008 - "The review is mostly focused on 18F-labeled probes designed for amino acid transport and protein synthesis, DNA synthesis, membrane lipid, and hypoxia such as FET, FLT, FMAU, fluorocholine, and FMISO, together with our original probes of FMT and FRP-170."
2.	Ganglioglioma 08/01/2010 - "The FRP-170 was injected and PET imaging was performed 2 hours later in 8 patients, including 3 with glioblastoma multiforme, 2 with oligodendroglioma, and 1 each with diffuse astrocytoma, anaplastic ganglioglioma, and recurrent anaplastic astrocytoma. "
3.	Oligodendroglioma 08/01/2010 - "The FRP-170 PET images showed marked uptake with upregulation of HIF-1alpha in the 3 glioblastomas multiforme, and moderate uptake in the recurrent anaplastic astrocytoma and one oligodendroglioma, but no uptake in the other tumors. " 08/01/2010 - "The FRP-170 was injected and PET imaging was performed 2 hours later in 8 patients, including 3 with glioblastoma multiforme, 2 with oligodendroglioma, and 1 each with diffuse astrocytoma, anaplastic ganglioglioma, and recurrent anaplastic astrocytoma. "
4.	Neoplasms (Cancer) 08/01/2010 - "The FRP-170 PET images showed marked uptake with upregulation of HIF-1alpha in the 3 glioblastomas multiforme, and moderate uptake in the recurrent anaplastic astrocytoma and one oligodendroglioma, but no uptake in the other tumors. "
5.	Glioma (Gliomas) 08/01/2010 - "Imaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. "

Related Drugs and Biologics

1.	Lactic Acid (Lactate)
2.	Protons (Proton)
3.	Proteins (Proteins, Gene)
4.	Membrane Lipids
5.	DNA (Deoxyribonucleic Acid)
6.	Amino Acids
7.	fluorocholine
8.	clevudine
9.	fluoromisonidazole