HLA-B*52:01 antigen

Also Known As:

HLA B*5201; HLA-B*5201; HLA-B*52:01

Networked: 10 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B52 Antigen: 22
        HLA-B*52:01 antigen: 10

Experts

1.	Takiguchi, Masafumi: 4 articles (01/2021 - 01/2017)
2.	Chikata, Takayuki: 3 articles (01/2021 - 01/2017)
3.	Gatanaga, Hiroyuki: 3 articles (01/2021 - 01/2017)
4.	Kuse, Nozomi: 3 articles (01/2021 - 01/2017)
5.	Murakoshi, Hayato: 3 articles (01/2021 - 01/2017)
6.	Oka, Shinichi: 3 articles (01/2021 - 01/2017)
7.	Akahoshi, Tomohiro: 2 articles (01/2021 - 01/2021)
8.	Koyanagi, Madoka: 2 articles (12/2017 - 01/2017)
9.	Hojo, Masayuki: 1 article (01/2021)
10.	Izumi, Shinyu: 1 article (01/2021)

Related Diseases

1.	Disease Progression 01/01/2020 - "HLA-B52:01 has consistently been shown in other cohorts to be associated with protection against HIV disease progression, but studies have been limited by the low prevalence of this allele in North America and Europe. " 01/01/2020 - "HLA-B52:01 is strongly associated with protection against HIV disease progression. " 01/01/2020 - "Consistent with studies of other cohorts, expression of HLA-B52:01 was associated with high absolute CD4 counts and therefore a lack of HIV disease progression. " 01/01/2017 - "HLA-B52:01-C12:02, which is the most abundant haplotype in Japan, has a protective effect on disease progression in HIV-1-infected Japanese individuals, whereas HLA-B57 and -B27 protective alleles are very rare in Japan. " 01/01/2017 - "In the present study, we demonstrated that these mutations were indeed selected by CTLs specific for novel B52:01- and C12:02-restricted epitopes and that the accumulation of these mutations reduced the viral fitness in vitro This study elucidated the mechanism by which the accumulation of these CTL escape mutations contributed to the protective effect of the HLA-B52:01-HLA-C*12:02 haplotype on disease progression in HIV-1-infected Japanese individuals."
2.	COVID-19 01/01/2021 - "In the HLA association studies, HLA-A11:01:01:01 [Pc = 0.013, OR = 2.26 (1.27-3.91)] and HLA-C12:02:02:01-HLA-B52:01:01:02 [Pc = 0.020, OR = 2.25 (1.24-3.92)] were found to be significantly associated with the severity of COVID-19. " 01/01/2021 - "HLA-A11:01:01:01, HLA-C12:02:02:01-HLA-B52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory Failure."
3.	Venous Thrombosis (Deep-Vein Thrombosis) 01/01/2005 - "In the patients carrying HLA-B5201 and/or -DPB10202, the frequency of deep vein thrombosis was significantly lower than the other patients. "
4.	Takayasu Arteritis (Arteritis, Takayasu's) 12/12/2017 - "HLA-B52:01-C12:02, which is found in approximately 20% of all Japanese persons, is well known to be associated with ulcerative colitis and Takayasu arteritis. "
5.	Respiratory Insufficiency (Respiratory Failure) 01/01/2021 - "HLA-A11:01:01:01, HLA-C12:02:02:01-HLA-B*52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory Failure."

Related Drugs and Biologics

1.	HLA-C Antigens (HLA-C)
2.	Epitopes
3.	HLA-A Antigens (HLA-A)
4.	Ligands
5.	HLA-B57 antigen