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alpha-toxicarol

from the roots of Derris trifoliata; structure in first source

Also Known As:

toxicarol

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Furukawa, Hiroshi: 2 articles (06/2004 - 01/2004)
2.	Ito, Chihiro: 2 articles (06/2004 - 01/2004)
3.	Itoigawa, Masataka: 2 articles (06/2004 - 01/2004)
4.	Kojima, Naoki: 2 articles (06/2004 - 01/2004)
5.	Nishino, Hoyoku: 2 articles (06/2004 - 01/2004)
6.	Takayasu, Junko: 2 articles (06/2004 - 01/2004)
7.	Tan, Hugh T-W: 2 articles (06/2004 - 01/2004)
8.	Tokuda, Harukuni: 2 articles (06/2004 - 01/2004)
9.	Cabieses, Fernando: 1 article (09/2003)
10.	Fong, Harry H S: 1 article (09/2003)

Related Diseases

1.	Carcinogenesis 06/01/2004 - "Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. " 01/01/2004 - "Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. "
2.	Neoplasms (Cancer) 06/01/2004 - "Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. " 01/01/2004 - "Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. "
3.	Lung Neoplasms (Lung Cancer) 12/01/2022 - "Of these, α-toxicarol displayed the best cytotoxicity against lung cancer (A549) and leukemic cells (K562) with the IC50 values of 104.4 and 67.5 μM, respectively. "
4.	Hepatocellular Carcinoma (Hepatoma) 09/01/2003 - "A new butenylflavanone, (2S)-5-hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone (1), and a new rotenoid, 4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin (2), as well as three active flavonoids of previously known structure, isoliquiritigenin (3), genistein (4), and chrysoeriol (5), along with nine known inactive compounds, alpha-toxicarol (6), sumatrol, 6a,12a-dehydro-alpha-toxicarol, 11-hydroxytephrosin, obovatin, marmesin, lupenone, benzyl benzoate, and benzyl trans-cinnamate, were isolated from an ethyl acetate-soluble extract of the stems of Tephrosia toxicaria, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. "

Related Drugs and Biologics

1.	deguelin
2.	Genistein
3.	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
4.	Flavonoids
5.	Cinnamates
6.	4',5'- dihydro- 11,5'- dihydroxy- 4'- methoxytephrosin
7.	lupenone
8.	isoliquiritigenin (GU 17)
9.	flavanone
10.	ethyl acetate