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pyropheophorbide 2-deoxyglucose

pyropheophorbide conjugate of 2-deoxyglucose that serves as a near-infrared fluorescent marker for tumors

Also Known As:

pyro-2DG

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Deoxy Sugars: 6
  - Deoxyglucose: 2901
    - pyropheophorbide 2-deoxyglucose: 2

Experts

1.	Chance, Britton: 2 articles (10/2004 - 07/2003)
2.	Li, Hui: 2 articles (10/2004 - 07/2003)
3.	Zhang, Min: 2 articles (10/2004 - 07/2003)
4.	Zhang, Zhihong: 2 articles (10/2004 - 07/2003)
5.	Zheng, Gang: 2 articles (10/2004 - 07/2003)
6.	Glickson, Jerry: 1 article (10/2004)
7.	Liu, Qian: 1 article (10/2004)
8.	Luo, Qingming: 1 article (10/2004)
9.	Zhou, Lanlan: 1 article (10/2004)
10.	Blessington, Dana: 1 article (07/2003)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2003 - "Fluorescence imaging studies demonstrate that Pyro-2DG is selectively accumulated in the tumor. " 07/01/2003 - "Preliminary confocal microscopy studies suggest that Pyro-2DG is delivered and trapped in tumor cells via the GLUT/hexokinase pathway and therefore is useful both as a tumor-targeted NIR fluorescence imaging probe and as a PDT agent for the destruction of cancer." 10/15/2004 - "The fact that only a low level of correlation was observed between the redox ratio and the uptake of Pyro-acid (the free fluorophore without the 2-deoxyglucose moiety) supports the hypothesis that Pyro-2DG is an index of the mitochondrial status (extent of PN reduction) of a tumor." 10/15/2004 - "In this study, we have evaluated the in vivo uptake of Pyro-2DG and found that Pyro-2DG selectively accumulated in two tumor models, 9L glioma in the rat and c-MYC-induced mammary tumor in the mouse, compared to surrounding normal muscle tissues at a ratio of about 10:1. By simultaneously performing redox ratio and fluorescence imaging, a high degree of correlation between the PN/(Fp+PN) redox ratio, where PN denotes reduced pyridine nucleotides (NADH) and Fp denotes oxidized flavoproteins, and the Pyro-2DG uptake was found in both murine tumor models, indicating that Pyro-2DG could serve as an extrinsic NIR fluorescent metabolic index for the tumors. "
2.	Glioma (Gliomas) 10/15/2004 - "In this study, we have evaluated the in vivo uptake of Pyro-2DG and found that Pyro-2DG selectively accumulated in two tumor models, 9L glioma in the rat and c-MYC-induced mammary tumor in the mouse, compared to surrounding normal muscle tissues at a ratio of about 10:1. By simultaneously performing redox ratio and fluorescence imaging, a high degree of correlation between the PN/(Fp+PN) redox ratio, where PN denotes reduced pyridine nucleotides (NADH) and Fp denotes oxidized flavoproteins, and the Pyro-2DG uptake was found in both murine tumor models, indicating that Pyro-2DG could serve as an extrinsic NIR fluorescent metabolic index for the tumors. "

Related Drugs and Biologics

1.	Nucleotides
2.	NAD (NADH)
3.	Hexokinase
4.	Flavoproteins
5.	pyridine
6.	1-phenyl-3,3-dimethyltriazene (PDT)
7.	Deoxyglucose (2 Deoxy D glucose)
8.	Acids