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A-705253

structure in first source

Also Known As:

N-(1-benzyl-2-carbamoyl-2-oxoethyl)-2-(E-2-(4-diethylaminomethylphenyl)ethen-1-yl)benzamide

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Neuhof, Christiane: 3 articles (12/2008 - 11/2004)
2.	Neuhof, Heinz: 3 articles (12/2008 - 11/2004)
3.	Möller, Achim: 2 articles (12/2008 - 11/2004)
4.	Speth, Maria: 2 articles (12/2008 - 11/2004)
5.	Tillmanns, Harald: 2 articles (12/2008 - 11/2004)
6.	Fritz, Hans: 2 articles (12/2005 - 11/2004)
7.	Baglietto-Vargas, David: 1 article (08/2012)
8.	Chabrier, Meredith A: 1 article (08/2012)
9.	Cheng, David: 1 article (08/2012)
10.	Green, Kim N: 1 article (08/2012)

Related Diseases

1.	Infarction (Infarctions) 12/28/2005 - "A-705253 reduced the infarct size by 35% compared to controls (P < 0.05). " 11/01/2004 - "The best effect was achieved with 10 -8 M A-705253 ( n =8), which reduced ( p <0.001) the infarcted area to 49.3+/-3.9% of the area at risk, corresponding to an infarct reduction of 61.8%. " 12/28/2005 - "This study investigates the cardioprotective effects of calpain inhibition on infarct size and global hemodynamics in an ischemia/reperfusion model in pigs, using the calpain inhibitor A-705253. "
2.	Ischemia 12/28/2005 - "Hemodynamic alterations, including heart rate, aortic blood pressure, central venous pressure and left atrial pressure, were attenuated mainly during ischemia and the first 2 h during reperfusion by A-705253. " 12/28/2005 - "A bolus of 1.0 mg/kg A-705253 or distilled water was given intravenously 15 min prior to induction of ischemia and a constant plasma level of A-705253 was maintained by continuous infusion of 1.0 mg/kg A-705253 during reperfusion. " 12/28/2005 - "This study investigates the cardioprotective effects of calpain inhibition on infarct size and global hemodynamics in an ischemia/reperfusion model in pigs, using the calpain inhibitor A-705253. "
3.	Myocardial Infarction 12/01/2008 - "Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts." 11/01/2004 - "Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts."
4.	Cognitive Dysfunction 08/01/2012 - "The administration of a novel inhibitor of calpain, A-705253, attenuated cognitive impairment and synaptic dysfunction in a dose-dependent manner in 3xTgAD mice. " 08/01/2012 - "Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice."
5.	Myocardial Ischemia (Ischemic Heart Diseases) 12/28/2005 - "Hence, the calpain-calpastatin system might play an important pathophysiological role in porcine myocardial ischemia and reperfusion damage and A-705253 could be a promising cardioprotective agent."

Related Drugs and Biologics

1.	calpain inhibitors
2.	Calpain
3.	Cardiotonic Agents (Cardiac Stimulants)
4.	A 705239
5.	cariporide
6.	calpastatin