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hemoglobin Crete

substitution: beta129(H7)Ala to Pro

Also Known As:

Hb Crete

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Crete: 3
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Crete: 3

Experts

1.	Kanavakis, Emmanuel: 1 article (05/2005)
2.	Kister, Jean: 1 article (05/2005)
3.	Liapi, Dimitra: 1 article (05/2005)
4.	Marden, Michael C: 1 article (05/2005)
5.	Papassotiriou, Ioannis: 1 article (05/2005)
6.	Prome, Danielle: 1 article (05/2005)
7.	Stamoulakatou, Alexandra: 1 article (05/2005)
8.	Traeger-Synodinos, Joanne: 1 article (05/2005)
9.	Wajcman, Henri: 1 article (05/2005)
10.	Christopoulou, Georgia: 1 article (01/2004)

Related Diseases

1.	Polycythemia (Erythrocytosis) 07/01/1979 - "His red cells contained 67% Hb Crete and 30% Hb F, and the combination of these two hemoglobins resulted in a blood P50O2 of 11.2 mm Hg. A brother with Hb Crete trait (38% Hb Crete, 56% Hb A, blood P50O2 23.0 mm Hg) did not have significant erythrocytosis. " 05/01/2005 - "The homozygous state for Hb Crete [beta129 (H7) Ala-->Pro] is associated with a complex phenotype including erythrocytosis and functional anemia." 07/01/1979 - "The propositus, who presented an unusual clinical picture of an "overcompensated" hemolytic state, with erythrocytosis, splenomegaly, abnormal red cell morphology, and marked erythroid hyperplasia, appeared doubly heterozygous for Hb Crete and deltabeta-thalassemia. " 05/01/2005 - "Hb Crete, an electrophoretically neutral, unstable, high oxygen affinity variant, was characterized by protein and DNA analyses in the homozygous state in a 32-year-old woman from Crete, with erythrocytosis and microcytosis. "
2.	Anemia 05/01/2005 - "The homozygous state for Hb Crete [beta129 (H7) Ala-->Pro] is associated with a complex phenotype including erythrocytosis and functional anemia." 01/01/2004 - "Both the proband and her mother, who were found to be heterozygotes for Hb Crete, presented with mild microcytic anemia and normal Hb A2 levels and iron metabolism indices. "
3.	Thalassemia 07/01/1979 - "Hemoglobin Crete (beta 129 ala leads to pro): a new high-affinity variant interacting with beta o -and delta beta o -thalassemia." 07/01/1979 - "The propositus, who presented an unusual clinical picture of an "overcompensated" hemolytic state, with erythrocytosis, splenomegaly, abnormal red cell morphology, and marked erythroid hyperplasia, appeared doubly heterozygous for Hb Crete and deltabeta-thalassemia. " 07/01/1979 - "Hemoglobin Crete, beta129 (h7)ala leads to pro, is a new mutant hemoglobin (Hb) with high oxygen affinity that was discovered in a Greek family in various combinations with beta- and deltabeta-thalassemia. "
4.	Splenomegaly 07/01/1979 - "The propositus, who presented an unusual clinical picture of an "overcompensated" hemolytic state, with erythrocytosis, splenomegaly, abnormal red cell morphology, and marked erythroid hyperplasia, appeared doubly heterozygous for Hb Crete and deltabeta-thalassemia. "
5.	Hyperplasia 07/01/1979 - "The propositus, who presented an unusual clinical picture of an "overcompensated" hemolytic state, with erythrocytosis, splenomegaly, abnormal red cell morphology, and marked erythroid hyperplasia, appeared doubly heterozygous for Hb Crete and deltabeta-thalassemia. "

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Proteins (Proteins, Gene)
3.	Iron
4.	Hemoglobins (Hemoglobin)
5.	DNA (Deoxyribonucleic Acid)
6.	hemoglobin A2'
7.	alanylproline