NCX 1022

nitric oxide-releasing hydrocortisone with anti-inflammatory effects; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Inflammation (Inflammations) 11/01/2004 - "5 These results suggest that by releasing NO, NCX 1022 modulates one of the early events of skin inflammation: the recruitment of leukocytes to the site of inflammation. " 11/01/2004 - "3 Topical pre- and post-treatment with NCX 1022 (3 nmol) in C57BL6 mice not only reduced ear oedema formation in a dose-dependent manner, but also was significantly more effective than the parent compound during the initial stages of inflammation (from 1 to 5 h). " 11/01/2004 - "2 Since hydrocortisone is the most widely used anti-inflammatory drug for the treatment of skin inflammation, we compared the anti-inflammatory effects of hydrocortisone to an NO-releasing derivative of hydrocortisone, NCX 1022, in a murine model of irritant contact dermatitis, induced by epidermal application of benzalkonium chloride. "
2.	Contact Dermatitis (Eczema, Contact) 11/01/2004 - "Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis." 11/01/2004 - "2 Since hydrocortisone is the most widely used anti-inflammatory drug for the treatment of skin inflammation, we compared the anti-inflammatory effects of hydrocortisone to an NO-releasing derivative of hydrocortisone, NCX 1022, in a murine model of irritant contact dermatitis, induced by epidermal application of benzalkonium chloride. "

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Irritants (Vesicants)
3.	Hydrocortisone (Cortisol)
4.	Benzalkonium Compounds (Benzalkonium Chloride)