protein S Heerlen

has Ser460Pro mutation which does not affect its APC-cofactor and APC-independent anticoagulant activities

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

1.	Venous Thrombosis (Deep-Vein Thrombosis) 03/01/2022 - "A Case of a Pediatric Patient With Protein S Heerlen Polymorphism and Deep Venous Thrombosis." 01/01/2017 - "Protein S Heerlen mutation heterozygosity is associated with venous thrombosis risk." 06/01/2004 - "If not, the reduction of free protein S levels in heterozygous protein S Heerlen-carriers combined with (low) normal total protein S levels apparently minimally affects the total anticoagulant activity of protein S (APC-cofactor and APC-independent activity) and hence is not associated with increased risk of venous thrombosis."
2.	Thrombosis (Thrombus) 10/01/2004 - "Because protein S-Heerlen is not associated with thrombosis, we investigated whether PS-C4BP is directly anticoagulant in plasma and whether PS-Heerlen-C4BP has enhanced direct anticoagulant activity. " 07/15/2000 - "These in vitro results suggest a possible mechanism of synergy between protein S Heerlen and factor V Leiden that might be involved in the pathogenesis of thrombosis in individuals carrying both genetic traits. "
3.	Protein S Deficiency (Deficiency, Protein S) 04/15/1997 - "Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele."