8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- one

structure in first source

Also Known As:

KU57788; NU 7441; NU-7441; NU7441

Networked: 30 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: 30
  - Oxazines: 9
    - Morpholines: 6
      - 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: 30
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: 30

Experts

1.	Newell, David R: 3 articles (12/2017 - 05/2006)
2.	Saha, Debabrata: 3 articles (10/2017 - 02/2015)
3.	Curtin, Nicola J: 3 articles (01/2014 - 05/2006)
4.	Kopa, Paulina: 2 articles (01/2021 - 01/2020)
5.	Macieja, Anna: 2 articles (01/2021 - 01/2020)
6.	Pastwa, Elzbieta: 2 articles (01/2021 - 01/2020)
7.	Poplawski, Tomasz: 2 articles (01/2021 - 01/2020)
8.	Menon, Jyothi U: 2 articles (10/2017 - 05/2015)
9.	Nguyen, Kytai T: 2 articles (10/2017 - 05/2015)
10.	Zhang, Zhang: 2 articles (10/2017 - 02/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In this study, we found that NU7441 alone significantly increased tumor growth in 4 T1 (a mouse TNBC cell line) tumor-bearing mice. " 01/01/2023 - "Moreover, NU7441 significantly decreased the percentage of MDSCs in peripheral blood mononuclear cells (PBMCs), spleen and tumor, but enhanced the immunosuppressive function of splenic MDSCs. " 01/01/2023 - "However, the effect of NU7441 on the tumor progression activity of immunosuppressive myeloid-derived suppressor cells (MDSCs) in TNBC remains unclear. " 05/15/2006 - "In mice bearing SW620 xenografts, NU7441 concentrations in the tumor necessary for chemopotentiation in vitro were maintained for at least 4 hours at nontoxic doses. " 01/01/2017 - "These studies reveal that Reg and NU7441 influence the immunobiology of both tumor cells and T cells and enhance the efficacy of various immunotherapies. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/28/2015 - "In this study, the combined effect of NU7441 and ionizing radiation (IR) in a panel of non-small cell lung cancer cell lines (A549, H460 and H1299) has been investigated. " 01/01/2017 - "In this study, we investigated the effect of NU7441, a synthetic small-molecule compound, as a specific inhibitor of DNA-PK on the chemosensitization of non-small cell lung carcinoma (NSCLC) A549 cells. " 01/01/2017 - "DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair."
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2016 - "In this study, we investigated the effect of NU7441, a synthetic small-molecule compound, as a specific inhibitor of DNA-dependent protein kinase (DNA-PK) in radiosensitization of hepatocellular carcinoma HepG2 cells. "
4.	Adenocarcinoma 01/01/2021 - "In this study, we investigated the effect of two NHEJ inhibitors, SCR7 and NU7441, on the cytotoxic mechanism of VP-16/CDDP in a LoVo human colorectal adenocarcinoma cell line. "
5.	Squamous Cell Carcinoma of Head and Neck 04/01/2023 - "DNA‑PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells." 01/01/2020 - "Taken together, these results demonstrate that the combination of NU7441 and olaparib with IR enhances HPV-negative HNSCC inhibition in both cell culture and in mice, suggesting a potential innovative combination for effectively treating patients with HPV-negative HNSCC." 12/01/2019 - ": Two PARP1 inhibitors (olaparib, veliparib) and two DNA-PK inhibitors (KU57788, IC87361) were tested in 14 HNSCC cell lines and two non-tumorigenic lines (HEK-293 and WI-38/Va-13), with drug exposure for 6 or 24 h post-irradiation, using regrowth assays. " 12/01/2019 - ": The DNA-PK inhibitors KU57788 and IC87361 are more effective radiosensitizers than the PARP-1 inhibitors olaparib and veliparib at non-cytotoxic concentrations in HNSCC cell cultures and their activity is enhanced by SLFN11 and hypoxia."

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Related Therapies and Procedures

1.	Immunotherapy
2.	Radiotherapy
3.	Therapeutics