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aplaviroc

a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source
Also Known As:
4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride; GW873140; benzoic acid, 4-(4-(((3R)-1-butyl-3-((R)-cyclohexylhydroxymethyl)-2,5-dioxo-1,4,9- triazaspiro(55)undec-9-yl)methyl)phenoxy)-; rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid
Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Maeda, Kenji: 2 articles (06/2008 - 02/2005)
2. Mitsuya, Hiroaki: 2 articles (06/2008 - 02/2005)
3. Nakata, Hirotomo: 2 articles (06/2008 - 02/2005)
4. Takaoka, Yoshikazu: 2 articles (06/2008 - 02/2005)
5. Cao, Z: 1 article (12/2020)
6. Liu, Z M: 1 article (12/2020)
7. Wang, L T: 1 article (12/2020)
8. Corbeau, P: 1 article (03/2010)
9. Psomas, K C: 1 article (03/2010)
10. Reynes, J: 1 article (03/2010)

Related Diseases

1. HIV Infections (HIV Infection)
2. Infections
3. Chemical and Drug Induced Liver Injury
4. Acquired Immunodeficiency Syndrome (AIDS)

Related Drugs and Biologics

1. Maraviroc
2. vicriviroc
3. Interleukin Receptor Common gamma Subunit
4. RNA (Ribonucleic Acid)
5. ONO 4128
6. 4-((4-((3R)-1-butyl-3-((1R)) cyclohexylhy- droxymethyl)- 2,5- dioxo- 1,4,9- triazaspiro(5.5)undec- 9- yl methyl)phenoxy)benzoic acid hydrochloride