S 23521

Glucagon-like peptide 1 (GLP-1) analog, considered potential drug for treatment of type 2 diabetes

Also Known As:

(a8-des R36) GLP-1-(7-37)-NH2; S23521

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Proglucagon: 128
        Glucagon: 7145
        S 23521: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protein Precursors: 37
    - S 23521: 2
- Peptides: 82426
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Proglucagon: 128
        Glucagon: 7145
        S 23521: 2
  - Peptide Fragments: 373
    - S 23521: 2

Experts

1.	Berthault, M-F: 1 article (03/2005)
2.	Cerasi, E: 1 article (03/2005)
3.	Chavanieu, A: 1 article (03/2005)
4.	Delagrange, P: 1 article (03/2005)
5.	Grassy, G: 1 article (03/2005)
6.	Kaiser, N: 1 article (03/2005)
7.	Ktorza, A: 1 article (03/2005)
8.	Leibowitz, G: 1 article (03/2005)
9.	Uçkaya, G: 1 article (03/2005)
10.	Canals, Ignasi: 1 article (10/2004)

Related Diseases

1.	Obesity 10/01/2004 - "These results strongly support S 23521 as a putative molecule for the treatment of obesity." 10/01/2004 - "S 23521 is an effective glucagon-like peptide-1-(7-36) amide analogue, which induced a decrease in energy intake, body weight, and adiposity in a rat model of diet-induced obesity. "
2.	Type 2 Diabetes Mellitus (MODY) 03/01/2005 - "These effects are probably due to actions of S 23521 both directly on islets and via reduced food intake, and emphasize the feasibility of preventing blood glucose deterioration over time in type 2 diabetes." 03/01/2005 - "We studied the effect of a novel GLP-1 analogue, S 23521 ([a8-des R36] GLP-1-[7-37]-NH2), on the metabolic state and beta-cell function, proliferation and survival in the Psammomys obesus model of diet-induced type 2 diabetes. " 03/01/2005 - "Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue."
3.	Body Weight (Weight, Body) 10/01/2004 - "S 23521 decreases food intake and body weight gain in diet-induced obese rats." 10/01/2004 - "S 23521 is an effective glucagon-like peptide-1-(7-36) amide analogue, which induced a decrease in energy intake, body weight, and adiposity in a rat model of diet-induced obesity. " 10/01/2004 - "To investigate the effect of S 23521, a new glucagon-like peptide-1-(7-36) amide analogue, on food intake and body weight gain in obese rats, as well as on gene expression of several proteins involved in energy homeostasis. "

Related Drugs and Biologics

1.	Glucagon-Like Peptide 1 (GLP 1)
2.	Proteins (Proteins, Gene)
3.	Glucagon (Glukagon)
4.	Blood Glucose (Blood Sugar)
5.	Amides