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WAY-169916

nonsteroidal selective NF-kappaB inhibitor; structure in first source

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - WAY-169916: 5

Experts

1.	Harnish, Douglas C: 3 articles (06/2006 - 12/2004)
2.	Kilbourne, Edward J: 2 articles (06/2007 - 06/2006)
3.	Kenney, Thomas: 2 articles (06/2006 - 12/2004)
4.	Borges-Marcucci, Lisa: 2 articles (01/2005 - 12/2004)
5.	Chadwick, Christopher C: 2 articles (01/2005 - 12/2004)
6.	Keith, James C: 2 articles (01/2005 - 12/2004)
7.	Steffan, Robert J: 2 articles (01/2005 - 12/2004)
8.	Amin, Shantu: 1 article (02/2010)
9.	Chiaro, Chris: 1 article (02/2010)
10.	Dinatale, Brett C: 1 article (02/2010)

Related Diseases

1.	Reperfusion Injury 06/01/2006 - "In the current study, WAY-169916 and 17beta-estradiol (17beta-E2) were evaluated for protective activity in models of cardiac ischemia-reperfusion injury. " 06/01/2007 - "In the present study, the pathway-selective ER ligand WAY-169916 was assessed for its cardioprotective potential in an in vivo model of ischemia-reperfusion injury. " 06/01/2006 - "In rats subjected to cardiac ischemia-reperfusion injury by occlusion of the left coronary artery, infarct size relative to the area at risk in the left ventricle was significantly attenuated by a single dose of 17beta-E2 (20 microg/kg, SC), and WAY-169916 administered SC (10 mg/kg) or IV (1 mg/kg) during the ischemia phase. " 06/01/2006 - "The pathway-selective estrogen receptor ligand WAY-169916 displays differential activity in ischemia-reperfusion injury models."
2.	Infarction (Infarctions) 06/01/2007 - "Acute treatment with either WAY-169916 or E2 resulted in a decrease in infarct size, expressed as a percent of area at risk (WAY-169916, 21.2 +/- 3.3; P < 0.001 and E2, 18.8 +/- 1.7; P < 0.001) compared with vehicle 59.4 +/- 5.4). " 06/01/2006 - "In rats subjected to cardiac ischemia-reperfusion injury by occlusion of the left coronary artery, infarct size relative to the area at risk in the left ventricle was significantly attenuated by a single dose of 17beta-E2 (20 microg/kg, SC), and WAY-169916 administered SC (10 mg/kg) or IV (1 mg/kg) during the ischemia phase. " 06/01/2007 - "The pathway-selective estrogen receptor ligand WAY-169916 reduces infarct size after myocardial ischemia and reperfusion by an estrogen receptor dependent mechanism."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2007 - "The pathway-selective estrogen receptor ligand WAY-169916 reduces infarct size after myocardial ischemia and reperfusion by an estrogen receptor dependent mechanism."
4.	Ischemia 06/01/2006 - "In isolated hearts perfused on a Langendorff apparatus and subjected to global ischemia and reperfusion, 17beta-E2 and WAY-169916 both had direct cardioprotective activity when perfused at 1 microM but their effects varied between different end points. " 06/01/2006 - "Perfusion with WAY-169916 attenuated the elevation in perfusion pressure, diastolic pressure, and release of creatine kinase after ischemia. " 06/01/2006 - "In rats subjected to cardiac ischemia-reperfusion injury by occlusion of the left coronary artery, infarct size relative to the area at risk in the left ventricle was significantly attenuated by a single dose of 17beta-E2 (20 microg/kg, SC), and WAY-169916 administered SC (10 mg/kg) or IV (1 mg/kg) during the ischemia phase. "
5.	Inflammation (Inflammations) 01/01/2005 - "Together, these data suggest the utility of WAY-169916, and other compounds in its class, in treating RA through global suppression of inflammation via selective blockade of NF-kappaB transcriptional activity."

Related Drugs and Biologics

1.	Ligands
2.	Estrogen Receptors
3.	NF-kappa B (NF-kB)
4.	Cytokines
5.	HLA-B27 Antigen (HLA B27 Antigen)
6.	Estrogens (Estrogen)
7.	Creatine Kinase (Creatine Phosphokinase)

Related Therapies and Procedures

1.	Oral Administration