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SK-7041

an antineoplastic agent; structure in first source

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - SK-7041: 6
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        SK-7041: 6

Experts

1.	Bang, Yung-Jue: 3 articles (09/2006 - 08/2004)
2.	Jong, Hyun-Soon: 2 articles (09/2006 - 08/2004)
3.	Kim, Noe Kyeong: 2 articles (09/2006 - 08/2004)
4.	Kim, Sang Gyun: 2 articles (09/2006 - 08/2004)
5.	Kim, Tae-You: 2 articles (09/2006 - 08/2004)
6.	Kim, Tai Young: 2 articles (09/2006 - 08/2004)
7.	Park, Jung-Hyun: 2 articles (09/2006 - 08/2004)
8.	Kim, Hak Jae: 1 article (12/2013)
9.	Kim, Il Han: 1 article (12/2013)
10.	Kim, In Ah: 1 article (12/2013)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2006 - "Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation. " 09/01/2006 - "SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. " 08/01/2004 - "Finally, in vivo experiment showed that SK-7041 or SK-7068 was found to reduce the growth of implanted human tumors in nude mice. " 08/01/2004 - "In this study we evaluated the antitumor effects of these novel hybrid synthetic HDAC inhibitors, SK-7041 and SK-7068, on human cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 09/01/2006 - "In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines. " 09/01/2006 - "Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA). " 09/01/2006 - "Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells."
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/01/2007 - "SK-7041 showed synergism on growth inhibition, cell cycle arrest and induction of apoptosis in chronic myeloid leukemia (K562) when combined with STI571. " 07/01/2007 - "Combination of SK-7041, one of novel histone deacetylase inhibitors, and STI571-induced synergistic apoptosis in chronic myeloid leukemia." 07/01/2007 - "Taken together, our findings suggest that SK-7041 is active against leukemia and offers new prospects for overcoming STI571 resistance in chronic myeloid leukemia."
4.	Stomach Neoplasms (Stomach Cancer) 08/01/2004 - "Growth inhibition effect of SK-7041 and SK-7068 was related with the induction of aberrant mitosis and apoptosis in human gastric cancer cells. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 06/08/2006 - "TSA and SK-7041 both induced apoptosis and G2-M cell cycle arrest in pancreatic cancer cell lines. " 06/08/2006 - "SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines."

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	SK-7068
3.	theasinensin A
4.	trichostatin A (A 300)
5.	Cyclin B1
6.	Caspases
7.	Cyclin E
8.	Valproic Acid (Depakote)
9.	Histones (Histone)
10.	Angiotensin II