2-hydroxy-9-cis-octadecenoic acid

03/01/2010 - "Studies carried out in a wide variety of cancer cell types demonstrated that apoptosis was the main molecular mechanism triggered by Minerval. "
01/01/2019 - "Additionally, compared with other OxPhos inhibitors, Minerval uniquely induced ER stress in cancer cell lines. "
01/01/2019 - "Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity."
03/01/2010 - "This is the first report on the pro-apoptotic activity of Minerval, and in part explains the effectiveness of this non-toxic anticancer drug and its wide spectrum against different types of cancer."
03/01/2010 - "Here we show that Minerval also induced apoptosis in Jurkat T-lymphoblastic leukaemia and other cancer cells. "

03/01/2010 - "Minerval is an oleic acid synthetic analogue that impairs lung cancer (A549) cell proliferation upon modulation of the plasma membrane lipid structure and subsequent regulation of protein kinase C localization and activity. "

06/01/2014 - "This review summarizes the cellular bases of the effects of NaCHOleate (2-hydroxyoleic acid; 2OHOA; Minerval) against glioma and other types of tumors. "

01/01/2019 - "As a function of its exposure time, Minerval compromised the capacity of glioblastoma U87-MG cells to compensate for aberrant respiration by up-modulation of glycolysis. "

01/01/2019 - "This effect was not exposure time-dependent in the lung carcinoma A549 cell line, which was more sensitive to Minerval. "