eugenosedin-A

antioxidant; protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice

Also Known As:

4-(2-hydroxy-3-(1-(2-chlorophenyl)piperazinyl))propoxy(-3-methoxy-1-propylenylbenzene)

Networked: 9 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - eugenosedin-A: 9

Experts

1.	Wu, Bin-Nan: 9 articles (01/2022 - 01/2005)
2.	Shen, Kuo-Ping: 8 articles (01/2022 - 06/2007)
3.	Lin, Hui-Li: 6 articles (04/2021 - 04/2009)
4.	Chen, Ing-Jun: 6 articles (03/2014 - 01/2005)
5.	Hsieh, Su-Ling: 4 articles (01/2022 - 06/2007)
6.	An, Li-Mei: 4 articles (03/2018 - 06/2011)
7.	Chang, Wen-Tsan: 3 articles (03/2014 - 06/2011)
8.	Lin, Jou-Chun: 2 articles (03/2014 - 02/2013)
9.	Chang, Yu-Chin: 1 article (01/2022)
10.	Juan, Yung-Shun: 1 article (01/2022)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 06/01/2007 - "In this study, we investigate the protective effects of eugenosedin-A on p38 mitogen-activated protein kinase (MAPK), inflammatory nitric oxide (NO) and cyclooxygenase-2 (COX-2) pathways in a rat model of endotoxin shock. "
2.	Hyperlipidemias (Hyperlipidemia) 01/01/2022 - "Eugenosedin-A (Eu-A) has been shown to protect against hyperglycemia- and hyperlipidemia-induced metabolic syndrome. " 03/01/2014 - "Eugenosedin-A ameliorates hyperlipidemia-induced vascular endothelial dysfunction via inhibition of α1-adrenoceptor/5-HT activity and NADPH oxidase expression."
3.	Inflammation (Inflammations) 06/01/2011 - "This study aimed to investigate the mechanisms of action of eugenosedin-A on endothelial function and inflammation in hyperlipidaemic mice. " 02/01/2013 - "Previous studies have shown eugenosedin-A, a 5-HT(1B/2A) and α(1)/α(2)/β(1)-adrenergic blocker, is able to decrease cholesterol levels, hyperglycaemia and inflammation in hyperlipidaemic mice induced by high-fat diet (HFD). "
4.	Diabetes Mellitus 03/01/2018 - "This study examined the effects of eugenosedin-A (Eu-A) in a streptozotocin (STZ)/nicotinamide-induced rat model of type II diabetes mellitus (T2DM). " 04/27/2021 - "The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR."
5.	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/27/2021 - "Eugenosedin-A (Eu-A), an adrenergic and serotonergic antagonist, is known to have anti-metabolic syndrome effects. " 01/01/2022 - "Eugenosedin-A (Eu-A) has been shown to protect against hyperglycemia- and hyperlipidemia-induced metabolic syndrome. "

Related Drugs and Biologics

1.	Cyclooxygenase 2 (Cyclooxygenase-2)
2.	p38 Mitogen-Activated Protein Kinases
3.	Nitric Oxide (Nitrogen Monoxide)
4.	NADPH Oxidases (NAD(P)H oxidase)
5.	Adrenergic Receptors (Adrenergic Receptor)
6.	Adrenergic Antagonists (Antiadrenergic Agents)
7.	Streptozocin (Streptozotocin)
8.	Niacinamide (Nicotinamide)
9.	Cholesterol
10.	Interleukin-1beta (Interleukin 1 beta)

Related Therapies and Procedures

1.	Intravenous Administration