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R 135853

a sordarin derivative with antifungal activity; structure in first source

Also Known As:

R-135853; R135853

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - R 135853: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - R 135853: 1
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - R 135853: 1

Experts

1.	Fukuoka, Takashi: 1 article (01/2005)
2.	Kakuta, Masayo: 1 article (01/2005)
3.	Kamai, Yasuki: 1 article (01/2005)
4.	Kuwahara, Shogo: 1 article (01/2005)
5.	Shibayama, Takahiro: 1 article (01/2005)

Related Diseases

1.	Candidiasis (Moniliasis) 01/01/2005 - "albicans, with MICs ranging from 0.03 to 0.06 mug/ml. However, R-135853 exhibited weak or no activity against Candida parapsilosis, Candida krusei, and Aspergillus spp. R-135853 exhibited dose-dependent efficacy against experimental murine hematogenous candidiasis induced by C. " 01/01/2005 - "Subcutaneous administration of R-135853 exhibited dose-dependent efficacy against experimental murine esophageal candidiasis induced by fluconazole-resistant C. " 01/01/2005 - "Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice." 01/01/2005 - "These results suggest that R-135853 is promising for the treatment of disseminated or mucosal candidiasis, including fluconazole-refractory infections."
2.	Infections 01/01/2005 - "These results suggest that R-135853 is promising for the treatment of disseminated or mucosal candidiasis, including fluconazole-refractory infections."

Related Drugs and Biologics

1.	Fluconazole (Zonal)
2.	sordarin