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IB4-saporin conjugate

Also Known As:

IB4-SAP

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - N-Glycosyl Hydrolases: 36
        Ribosome Inactivating Proteins: 51
        Type 1 Ribosome Inactivating Proteins: 3
        Saporins: 330
        IB4-saporin conjugate: 3
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - IB4-saporin conjugate: 3
  - Plant Proteins: 334
    - Ribosome Inactivating Proteins: 51
      - Type 1 Ribosome Inactivating Proteins: 3
        Saporins: 330
        IB4-saporin conjugate: 3

Experts

1.	Kras, Jeffrey V: 2 articles (08/2017 - 09/2015)
2.	Pall, Parul S: 2 articles (08/2017 - 09/2015)
3.	Weisshaar, Christine L: 2 articles (08/2017 - 09/2015)
4.	Winkelstein, Beth A: 2 articles (08/2017 - 09/2015)
5.	Kartha, Sonia: 1 article (08/2017)
6.	Bae, Sam S: 1 article (02/2014)
7.	Bernabé, Daniel: 1 article (02/2014)
8.	Schmidt, Brian L: 1 article (02/2014)
9.	Troob, Scott: 1 article (02/2014)
10.	Viet, Chi T: 1 article (02/2014)

Related Diseases

1.	Hyperalgesia 02/13/2014 - "Selective ablation of IB4(+) neurons by IB4-SAP decreased mechanical allodynia in mice with SCC. " 08/10/2017 - "Behavioral sensitivity, thalamic glutamate transporter expression, and thalamic hyperexcitability were evaluated up to and at day 7. Administering IB4-SAP prior to a painful injury prevented the development of mechanical hyperalgesia that is typically present. " 02/13/2014 - "Selective ablation of TRPV1(+) neurons by intrathecal capsaicin injection, or TRPV1 antagonism by JNJ-17203212 in the IB4-SAP treated mice completely reversed SCC-induced thermal hyperalgesia, without affecting mechanical allodynia. "
2.	Hypersensitivity (Allergy) 09/14/2015 - "SSP-Sap, but not IB4-Sap, injected into the bilateral C6/C7 facet joints 14 days prior to an intra- articular NGF injection prevents NGF-induced mechanical and thermal hypersensitivity in the forepaws. "

Related Drugs and Biologics

1.	Amino Acid Transport System X-AG (Glutamate Transporter)
2.	Nerve Growth Factor (NGF)
3.	Capsaicin (Zostrix)
4.	4- (3- trifluoromethylpyridin- 2- yl)piperazine- 1- carboxylic acid (5-trifluoromethylpyridin-2-yl)amide