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N- (4- acetylphenyl)- 2- (4- (2,3,6,7- tetrahydro- 2,6- dioxo- 1,3- dipropyl- 1H- purin- 8- yl)phenoxy)acetamide

J Neurochem 2004 Dec;91(5):1180-90

Also Known As:

MRS 1706; MRS-1706; MRS1706

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - N-(4-acetylphenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy)acetamide: 5

Experts

1.	Biber, Knut: 1 article (01/2015)
2.	Eusemann, Till Nicolas: 1 article (01/2015)
3.	Fiebich, Bernd: 1 article (01/2015)
4.	Willmroth, Frank: 1 article (01/2015)
5.	van Calker, Dietrich: 1 article (01/2015)
6.	Keyhanmanesh, Rana: 1 article (01/2014)
7.	Khalili, Majid: 1 article (01/2014)
8.	Mirzamohammadi, Zahra: 1 article (01/2014)
9.	Omrani, Hasan: 1 article (01/2014)
10.	Pejman, Laleh: 1 article (01/2014)

Related Diseases

1.	Infarction (Infarctions) 10/01/2012 - "The infarct reducing effect of EGCG was significantly reversed by 200 nM of the A(1) ADR antagonist DPCPX (25.9 ± 1.1%, P < 0.05) and 15 nM of the A(2B) ADR antagonist MRS1706 (29.3 ± 1.7%, P < 0.01) but not by 10 µM of the A(2A) ADR antagonist ZM241385 (23.9 ± 1.9%. " 11/01/2009 - "The adenosine A1/A2 receptor agonist 5'-(N-ethylcarboxamido) adenosine (NECA) given at reperfusion reduced infarct size, an effect that was reversed by both the adenosine A2A antagonist SCH58261 and the A2B antagonist MRS1706. "
2.	Astrocytoma (Pilocytic Astrocytoma) 01/01/2015 - "However while this effect was mediated by A2B receptors in astrocytoma cells it was mediated by A2A receptors in astrocytes as assessed by the order of potency of agonists and selective blockade by the specific antagonists MRS1706 and ZM241385 respectively. "
3.	Asthma (Bronchial Asthma) 01/01/2014 - "For determining the effect of different A2 receptors, in this investigation the effect of single dose of selective adenosine A2A and A2B antagonists (ZM241385 and MRS1706) on different inflammatory parameters; tracheal responsiveness to methacholine and ovalbumin, total and differential cell count in bronchoalveolar lavage (BAL), blood levels of IL-4 and IFN-γ and lung pathology of guinea pig model of asthma were assessed. "
4.	Hypoxia (Hypoxemia) 11/01/2013 - "Involvement of A2B receptor was implied in hypoxia-induced angiogenesis as MRS-1706 (10nM), a selective A2B antagonist attenuated NECA (10 μM)-induced angiogenesis. "

Related Drugs and Biologics

1.	ZM 241385 (ZM241385)
2.	Adenosine-5'-(N-ethylcarboxamide) (NECA)
3.	Adenosine (Adenocard)
4.	Methacholine Chloride (Methacholine)
5.	Interleukin-4 (Interleukin 4)
6.	Ovalbumin
7.	5- amino- 7- (2- phenylethyl)- 2- (2- furyl)pyrazolo(4,3- e)- 1,2,4- triazolo(1,5- c)pyrimidine
8.	1,3-dipropyl-8-cyclopentylxanthine