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fluorinase

catalyses the conversion of fluoride ion and S-adenosylmethionine to 5'-fluoro-5'-deoxyfluoroadenosine

Also Known As:

fluorinase, Streptomyces cattleya

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Bacterial Proteins: 394
    - fluorinase: 2
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - fluorinase: 2

Experts

1.	Dall'Angelo, Sergio: 1 article (07/2016)
2.	Fleming, Ian N: 1 article (07/2016)
3.	O'Hagan, David: 1 article (07/2016)
4.	Schweiger, Lutz F: 1 article (07/2016)
5.	Zanda, Matteo: 1 article (07/2016)
6.	Zhang, Qingzhi: 1 article (07/2016)
7.	Ashworth, S: 1 article (09/2015)
8.	Fleming, I N: 1 article (09/2015)
9.	O'Hagan, D: 1 article (09/2015)
10.	Onega, M: 1 article (09/2015)

Related Diseases

1.

Neoplasms (Cancer)

07/25/2016 - "The fluorinase was able to use this construct as a substrate for a transhalogenation reaction to generate [(18) F]-radiolabeled RGD peptides, which retained high affinity to cancer-cell relevant αv β3 integrins. "
09/11/2015 - "A two-step radiolabelling protocol of a cancer relevant cRGD peptide is described where the fluorinase enzyme is used to catalyse a transhalogenation reaction to generate [(18)F]-5'-fluoro-5'-deoxy-2-ethynyladenosine, [(18)F]FDEA, followed by a 'click' reaction to an azide tethered cRGD peptide. "

Related Drugs and Biologics

1.	Integrins
2.	Peptides (Polypeptides)
3.	Enzymes
4.	Azides
5.	cyclic arginine-glycine-aspartic acid peptide