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bis(2-chloroethoxy)methane

a solvent used in polysulfide elastomer production; structure in first source

Also Known As:

Ethane, 2,2'-(methylenebis(oxy))bis(1-chloro)-

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Ethyl Ethers: 3
    - bis(2-chloroethoxy)methane: 8

Experts

1.	Nyska, Abraham: 5 articles (12/2009 - 05/2004)
2.	Dunnick, June: 3 articles (12/2009 - 09/2004)
3.	Cristy, T: 1 article (08/2011)
4.	Dunnick, J K: 1 article (08/2011)
5.	Godfrey-Robinson, V D: 1 article (08/2011)
6.	Graves, S W: 1 article (08/2011)
7.	Hong, S P: 1 article (08/2011)
8.	Johnson, J D: 1 article (08/2011)
9.	Smith, C S: 1 article (08/2011)
10.	Waidyanatha, S: 1 article (08/2011)

Related Diseases

1.	Cardiotoxicity 08/28/2011 - "In the National Toxicology Program's toxicity studies, rats were more sensitive than mice to Bis(2-chloroethoxy)methane (CEM) - induced cardiac toxicity following dermal application to male and female F344/N rats and B6C3F1 mice. " 12/01/2009 - "Electron microscopy and light microscopy have been used to evaluate the cardiotoxicity of bis(2-chloroethoxy)methane (CEM) in F344/N rats and B6C3F1 mice. " 12/01/2009 - "The pivotal role of electron microscopic evaluation in investigation of the cardiotoxicity of bis(2-chloroethoxy)methane in rats and mice." 04/01/2007 - "Occult cardiotoxicity: subtoxic dosage of Bis(2-chloroethoxy)methane impairs cardiac response to simulated ischemic injury." 01/01/2006 - "Gene transcript changes after exposure to the heart toxin, bis(2-chloroethoxy)methane (CEM), were analyzed to elucidate mechanisms in cardiotoxicity and recovery. "
2.	Carcinogenesis 08/01/2011 - "Toxicology and carcinogenesis studies of bis(2-chloroethoxy)methane (CAS No. 111-91-1) in F344/N rats and B6C3F1 mice (dermal studies)."
3.	Thrombosis (Thrombus) 09/01/2004 - "Damage induced by bis(2-chloroethoxy)methane consisted of time-related development of myofiber vacuolation, necrosis, mononuclear-cell infiltration, fibrosis, and atrial thrombosis. " 01/01/2005 - "Incidences of atrial thrombosis were increased in high-dosed groups involving 13 compounds (incidence rate: 20-100%): 2-butoxyethanol, C.I. Direct Blue 15, bis(2-chloroethoxy)methane, diazoaminobenzene, diethanolamine, 3,3'-dimethoxybenzidine dihydrochloride, hexachloroethane, isobutene, methyleugenol, oxazepam, C.I. Pigment Red 23, C.I. Acid Red 114, and 4,4'-thiobis(6-t-butyl-m-cresol). "
4.	Necrosis 09/01/2004 - "Damage induced by bis(2-chloroethoxy)methane consisted of time-related development of myofiber vacuolation, necrosis, mononuclear-cell infiltration, fibrosis, and atrial thrombosis. "
5.	Ischemia 04/01/2007 - "The effect of Bis(2-chloroethoxy)methane (CEM) on myocardial response to ischemia was tested in rats. "

Related Drugs and Biologics

1.	Oxazepam (Serax)
2.	Dianisidine
3.	1- (2- methoxy- 5- nitrophenylazo)- 2- hydroxy- 3- (3- nitrophenylcarbamoyl)naphthalene (Red 23)
4.	1,3-diphenyl-1-triazene
5.	C.I. Acid Red 114
6.	4,4'-thiobis(6-tert-butyl-3-cresol)
7.	direct blue 15
8.	diethanolamine
9.	n-butoxyethanol (2-butoxyethanol)
10.	hexachloroethane

Related Therapies and Procedures

1.	Cutaneous Administration