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FR 167356

vacuolar ATPase inhibitor that acts particularly well on osteoclast vacuolar ATPase; structure in first source

Also Known As:

FR-167356; FR167356

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Niikura, Kazuaki: 2 articles (09/2005 - 06/2004)
2.	Takano, Mikiko: 2 articles (09/2005 - 06/2004)
3.	Hata, Kenji: 1 article (07/2011)
4.	Morita, Yoshihiro: 1 article (07/2011)
5.	Nakanishi, Masako: 1 article (07/2011)
6.	Nishisho, Toshihiko: 1 article (07/2011)
7.	Sun-Wada, Ge-Hong: 1 article (07/2011)
8.	Wada, Yoh: 1 article (07/2011)
9.	Yasui, Natsuo: 1 article (07/2011)
10.	Yoneda, Toshiyuki: 1 article (07/2011)

Related Diseases

1.	Bone Resorption 09/01/2005 - "Moreover, FR167356 was shown to restore BMD of ovariectomized rats caused by the inhibition of bone resorption. " 06/01/2004 - "As expected, FR167356 remarkably inhibited bone resorption in vitro. " 09/01/2005 - "A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application." 09/01/2005 - "Similarly, FR167356 inhibited bone resorption in vitro when stimulated by PTH, IL-1, and IL-6. " 06/01/2004 - "Moreover, LDL metabolism in cells, which depends on acidification of lysosome, was blocked merely at higher concentration than bone resorption, suggesting that FR167356 inhibits V-ATPase of osteoclast ruffled border membrane still more selectively than lysosome at the cellular level. "
2.	Neoplasm Metastasis (Metastasis) 07/01/2011 - "Importantly, administration of a specific V-ATPase a3 inhibitor FR167356 reduced bone metastasis of B16-F10 cells. "
3.	Hypercalcemia (Milk Alkali Syndrome) 09/01/2005 - "FR167356 reduced retinoic acid-induced hypercalcemia in thyroparathyroidectomized-ovariectomized rats in a dose-dependent manner. "
4.	Body Weight (Weight, Body) 09/01/2005 - "Ovariectomized rats treated with FR167356 did not show adverse symptoms, whereas SB242784 caused a decrease in body weight gain and significant changes in two plasma biochemical parameters. "

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Vacuolar Proton-Translocating ATPases (V-Type ATPase)
3.	Interleukin-6 (Interleukin 6)
4.	Tretinoin (Retinoic Acid)
5.	Interleukin-1 (Interleukin 1)
6.	oxidized low density lipoprotein