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(3,4- dihydro- 2H- pyrano(2,3)b- quinolin- 7- yl)- (cis- 4- methoxycyclohexyl) methanone

a mGlu1 receptor antagonist; structure in first source

Also Known As:

JNJ16259685

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - (3,4-dihydro-2H-pyrano(2,3)b-quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone: 11

Experts

1.	Jiang, Ming: 1 article (01/2020)
2.	Mi, Qiong-Jie: 1 article (01/2020)
3.	Song, Yu-Qiang: 1 article (01/2020)
4.	Sun, Bao-Liang: 1 article (01/2020)
5.	Wang, Wei-Qi: 1 article (01/2020)
6.	Yang, Ming-Feng: 1 article (01/2020)
7.	Yin, Yan-Xin: 1 article (01/2020)
8.	Zhang, Cheng: 1 article (01/2020)
9.	Zhang, Zong-Yong: 1 article (01/2020)
10.	Zhao, Shi-Jun: 1 article (01/2020)

Related Diseases

1.	Acute Pain 04/01/2005 - "JNJ16259685 did not increase water intake or reduce acute pain threshold, suggesting that the anxiolytic-like properties are specific. " 12/01/2011 - "The present study examined the effects of the mGluR1 antagonist JNJ16259685 (JNJ) and the mGluR5 antagonist 2-methyl-6-phenylethynylpyridine (MPEP) alone and in combination with morphine in two acute pain models (hotplate, warm water tail-withdrawal), and a persistent, inflammatory pain model (capsaicin). "
2.	Pain (Aches) 12/01/2011 - "The present study examined the effects of the mGluR1 antagonist JNJ16259685 (JNJ) and the mGluR5 antagonist 2-methyl-6-phenylethynylpyridine (MPEP) alone and in combination with morphine in two acute pain models (hotplate, warm water tail-withdrawal), and a persistent, inflammatory pain model (capsaicin). "
3.	Photophobia (Light Sensitivity) 01/01/2013 - "I found that JNJ16259685 increased light sensitivity of all ON-center RGCs and most OFF-center RGCs studied. "
4.	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/19/2013 - "In contrast, the mGlu5 receptor PAM, VU0360172 (10 mg/kg, s.c.), caused only a short-lasting improvement of motor symptoms, whereas the mGlu1 receptor antagonist, JNJ16259685 (2.5 mg/kg, i.p.), further impaired motor performance in SCA1 mice. "
5.	Shock 04/01/2011 - "JNJ16259685 (30 mg/kg) had no effect on reflexive startle responses to loud auditory stimuli or foot shock in mice. "

Related Drugs and Biologics

1.	metabotropic glutamate receptor type 1
2.	Morphine (MS Contin)
3.	Capsaicin (Zostrix)
4.	Glutamic Acid (Glutamate)
5.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
6.	Anti-Anxiety Agents (Anxiolytics)
7.	Analgesics (Analgesic Drugs)
8.	N- cyclobutyl- 6- ((3- fluorophenyl)ethynyl)nicotinamide
9.	7- (hydroxyimino)cyclopropan(b)chromen- 1a- carbxoylic acid ethyl ester
10.	1-aminoindan-1,5-dicarboxylic acid