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1-(aminomethyl)cyclohexaneacetic acid 3-(nitrooxymethyl)phenyl ester

a nitric oxide-releasing compound

Also Known As:

NCX 8001; NCX-8001; NCX8001

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Hao, Jing-Xia: 1 article (01/2004)
2.	Impagnatiello, Francesco: 1 article (01/2004)
3.	Ongini, Ennio: 1 article (01/2004)
4.	Presotto, Cristina: 1 article (01/2004)
5.	Wiesenfeld-Hallin, Zsuzsanna: 1 article (01/2004)
6.	Wu, Wei-Ping: 1 article (01/2004)
7.	Xu, Xiao-Jun: 1 article (01/2004)

Related Diseases

1.	Pain (Aches) 01/01/2004 - "7. Potentially due to the slow releasing kinetics of NO, NCX8001 alleviated pain-like behaviors in two rat models of neuropathic pain in a fashion that is superior to its parent counterpart gabapentin. "
2.	Neuralgia (Stump Neuralgia) 01/01/2004 - "7. Potentially due to the slow releasing kinetics of NO, NCX8001 alleviated pain-like behaviors in two rat models of neuropathic pain in a fashion that is superior to its parent counterpart gabapentin. " 01/01/2004 - "A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury." 01/01/2004 - "2. With this background, we synthesized a new chemical entity, [1-(aminomethyl)cyclohexane acetic acid 3-(nitroxymethyl)phenyl ester] NCX8001, which has a NO-releasing moiety bound to gabapentin, a drug currently used for the clinical management of neuropathic pain. "
3.	Peripheral Nerve Injuries 01/01/2004 - "A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury."
4.	Hyperalgesia 01/01/2004 - "6. NCX8001 alleviated the allodynia-like responses of rats to innocuous mechanical or cold stimulation following lesion of the sciatic nerve. "

Related Drugs and Biologics

1.	Gabapentin (Neurontin)
2.	Acetic Acid (Vinegar)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Esters
5.	Cyclohexane